| Literature DB >> 12951093 |
Krzysztof Krajewski1, Ya-Qiu Long, Christophe Marchand, Yves Pommier, Peter P Roller.
Abstract
Dimers of known HIV-1 integrase inhibitory hexapeptide H-His-Cys-Lys-Phe-Trp-Trp-NH(2) containing different lengths of cross linkers in the place of cysteine residue, were designed, and synthesized. The inhibitory potency of these dimeric peptides is consistently higher than the lead hexapeptide. The dimeric peptide with djenkolic acid linker exhibited IC(50) values of 5.3 and 6.5 microM, for 3'-end processing and strand transfer, respectively.Entities:
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Year: 2003 PMID： 12951093 DOI： 10.1016/s0960-894x(03)00679-6
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823