Literature DB >> 12951083

Biological activities of alpha-mangostin derivatives against acidic sphingomyelinase.

Motoko Hamada1, Kazuhiko Iikubo, Yuichi Ishikawa, Aya Ikeda, Kazuo Umezawa, Shigeru Nishiyama.   

Abstract

Deprenyl and benzofenone-type congeners of alpha-mangostin 1 have been synthesized to understand their role for the inhibitory activity against sphingomyelinase (SMase). While removal of the prenyl group of the right side (11 and 12) caused loss of the selectivity between ASMase (acidic sphingomyelinase) and NSMase (neutral sphingomyelinase), the prenyl group of the left side appeared to increase the inhibitory activities (16 and 17).

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12951083     DOI： 10.1016/s0960-894x(03)00719-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Structural Characterization, Biological Effects, and Synthetic Studies on Xanthones from Mangosteen (Garcinia mangostana), a Popular Botanical Dietary Supplement.

Authors:  Young-Won Chin; A Douglas Kinghorn
Journal:  Mini Rev Org Chem       Date:  2008-11-01       Impact factor: 2.495

2.  Total Synthesis of Tovophyllin B.

Authors:  Valer Jeso; K C Nicolaou
Journal:  Tetrahedron Lett       Date:  2009-03-18       Impact factor: 2.415

3.  Acid Sphingomyelinase Deficiency Ameliorates Farber Disease.

Authors:  Nadine Beckmann; Katrin Anne Becker; Stephanie Kadow; Fabian Schumacher; Melanie Kramer; Claudine Kühn; Walter J Schulz-Schaeffer; Michael J Edwards; Burkhard Kleuser; Erich Gulbins; Alexander Carpinteiro
Journal:  Int J Mol Sci       Date:  2019-12-11       Impact factor: 5.923
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.