Literature DB >> 12951080

Synthesis and cytotoxic activity of A-ring modified betulinic acid derivatives.

Young-Jae You1, Yong Kim, Nguyen-Hai Nam, Byung-Zun Ahn.   

Abstract

New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at C2 showed strong cytotoxicity.

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Year:  2003        PMID： 12951080     DOI： 10.1016/s0960-894x(03)00724-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10.

Authors:  Susanne U Mertens-Talcott; Giuliana D Noratto; Xiangrong Li; Gabriela Angel-Morales; Michele C Bertoldi; Stephen Safe
Journal:  Mol Carcinog       Date:  2012-03-07       Impact factor: 4.784

2.  Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A.

Authors:  Tadashi Honda; Karen T Liby; Xiaobo Su; Chitra Sundararajan; Yukiko Honda; Nanjoo Suh; Renee Risingsong; Charlotte R Williams; Darlene B Royce; Michael B Sporn; Gordon W Gribble
Journal:  Bioorg Med Chem Lett       Date:  2006-09-25       Impact factor: 2.823

3.  Trioxolone Methyl, a Novel Cyano Enone-Bearing 18βH-Glycyrrhetinic Acid Derivative, Ameliorates Dextran Sulphate Sodium-Induced Colitis in Mice.

Authors:  Andrey V Markov; Aleksandra V Sen'kova; Oksana V Salomatina; Evgeniya B Logashenko; Dina V Korchagina; Nariman F Salakhutdinov; Marina A Zenkova
Journal:  Molecules       Date:  2020-05-21       Impact factor: 4.411

4.  Betulinic Acid for cancer treatment and prevention.

Authors:  Simone Fulda
Journal:  Int J Mol Sci       Date:  2008-06-27       Impact factor: 6.208

5.  Synthesis and Evaluation of Anticancer Activities of Novel C-28 Guanidine-Functionalized Triterpene Acid Derivatives.

Authors:  Anna Spivak; Rezeda Khalitova; Darya Nedopekina; Lilya Dzhemileva; Milyausha Yunusbaeva; Victor Odinokov; Vladimir D'yakonov; Usein Dzhemilev
Journal:  Molecules       Date:  2018-11-16       Impact factor: 4.411
  5 in total

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