| Literature DB >> 12951079 |
Xenia Beebe1, Angela M Nilius, Philip J Merta, Niru B Soni, Mai H Bui, Rolf Wagner, Bruce A Beutel.
Abstract
The parallel synthesis and antibacterial activity of 5-hydroxy[1,2,5] oxadiazolo[3,4-b]pyrazines is reported. The compounds were synthesized by condensing diaminofurazan with alpha-keto acids to give a variety of aryl-substituted analogues. Halogenated phenyl groups at C-6 give rise to the greatest Haemophilus influenzae antibacterial activity.Entities:
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Year: 2003 PMID： 12951079 DOI： 10.1016/s0960-894x(03)00727-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823