BACKGROUND: There is controversy about whether late-onset schizophrenia is a precursor of cognitive decline. AIMS: To examine the long-term outcome of a group of patients with late-onset schizophrenia. METHOD: Patients with onset of DSM-III-R schizophrenia at age 50 years or over, but without dementia, and a healthy control group were assessed at baseline (n=27 and n=34, respectively), after 1 year and after 5 years (n=19 and n=24, respectively) on measures of psychopathology, cognition and general functioning, and compared on rates of decline and incidence of dementia. RESULTS: Nine patients with late-onset schizophrenia and none of the control group were found to have dementia (5 Alzheimer type, 1 vascular, 3 dementia of unknown type) at 5-year follow-up. There appeared to be a subgroup of late-onset schizophrenia patients without signs of dementia at baseline or at 1 year follow-up who subsequently declined. CONCLUSIONS: Late-onset schizophrenia may be a prodrome of Alzheimer-type dementia. More longitudinal studies are required to determine its nosological status.
BACKGROUND: There is controversy about whether late-onset schizophrenia is a precursor of cognitive decline. AIMS: To examine the long-term outcome of a group of patients with late-onset schizophrenia. METHOD:Patients with onset of DSM-III-R schizophrenia at age 50 years or over, but without dementia, and a healthy control group were assessed at baseline (n=27 and n=34, respectively), after 1 year and after 5 years (n=19 and n=24, respectively) on measures of psychopathology, cognition and general functioning, and compared on rates of decline and incidence of dementia. RESULTS: Nine patients with late-onset schizophrenia and none of the control group were found to have dementia (5 Alzheimer type, 1 vascular, 3 dementia of unknown type) at 5-year follow-up. There appeared to be a subgroup of late-onset schizophreniapatients without signs of dementia at baseline or at 1 year follow-up who subsequently declined. CONCLUSIONS: Late-onset schizophrenia may be a prodrome of Alzheimer-type dementia. More longitudinal studies are required to determine its nosological status.
Authors: Allen D Radant; Dorcas J Dobie; Monica E Calkins; Ann Olincy; David L Braff; Kristin S Cadenhead; Robert Freedman; Michael F Green; Tiffany A Greenwood; Raquel E Gur; Ruben C Gur; Gregory A Light; Sean P Meichle; Steve P Millard; Jim Mintz; Keith H Nuechterlein; Nicholas J Schork; Larry J Seidman; Larry J Siever; Jeremy M Silverman; William S Stone; Neal R Swerdlow; Ming T Tsuang; Bruce I Turetsky; Debby W Tsuang Journal: Psychophysiology Date: 2010-04-05 Impact factor: 4.016
Authors: Nikolas R Block; Sharon J Sha; Anna M Karydas; Jamie C Fong; Mary G De May; Bruce L Miller; Howard J Rosen Journal: Am J Geriatr Psychiatry Date: 2015-06-21 Impact factor: 4.105
Authors: Zahinoor Ismail; Byron Creese; Dag Aarsland; Helen C Kales; Constantine G Lyketsos; Robert A Sweet; Clive Ballard Journal: Nat Rev Neurol Date: 2022-01-04 Impact factor: 44.711
Authors: Tarek K Rajji; Aristotle N Voineskos; Meryl A Butters; Dielle Miranda; Tamara Arenovich; Mahesh Menon; Zahinoor Ismail; Robert S Kern; Benoit H Mulsant Journal: Am J Geriatr Psychiatry Date: 2013-01-22 Impact factor: 4.105