Literature DB >> 12948770

Sequence motifs, polar interactions and conformational changes in helical membrane proteins.

A Rachael Curran1, Donald M Engelman.   

Abstract

The alpha helices of transmembrane proteins interact to form higher order structures. These interactions are frequently mediated by packing motifs (such as GxxxG) and polar residues. Recent structural data have revealed that small sidechains are able to both stabilize helical membrane proteins and allow conformational changes in the structure. The strong interactions involving polar sidechains often contribute to protein misfolding or malfunction.

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Year:  2003        PMID： 12948770     DOI： 10.1016/s0959-440x(03)00102-7

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  93 in total

1.  Helical packing patterns in membrane and soluble proteins.

Authors:  Marina Gimpelev; Lucy R Forrest; Diana Murray; Barry Honig
Journal:  Biophys J       Date:  2004-10-01       Impact factor: 4.033

2.  On GxxxG in N-terminal stretches of type-1 VDAC/porin: critical in vertebrate apoptosis, missing in plants.

Authors:  Friedrich P Thinnes
Journal:  Plant Mol Biol       Date:  2012-03-27       Impact factor: 4.076

3.  Driving forces for transmembrane alpha-helix oligomerization.

Authors:  Alex J Sodt; Teresa Head-Gordon
Journal:  Biophys J       Date:  2010-07-07       Impact factor: 4.033

Review 4.  Structure elucidation of dimeric transmembrane domains of bitopic proteins.

Authors:  Eduard V Bocharov; Pavel E Volynsky; Konstantin V Pavlov; Roman G Efremov; Alexander S Arseniev
Journal:  Cell Adh Migr       Date:  2010-05-01       Impact factor: 3.405

Review 5.  Toward understanding protocell mechanosensation.

Authors:  Daniel Balleza
Journal:  Orig Life Evol Biosph       Date:  2010-11-17       Impact factor: 1.950

6.  Mechanism of membrane activity of the antibiotic trichogin GA IV: a two-state transition controlled by peptide concentration.

Authors:  Claudia Mazzuca; Lorenzo Stella; Mariano Venanzi; Fernando Formaggio; Claudio Toniolo; Basilio Pispisa
Journal:  Biophys J       Date:  2005-02-18       Impact factor: 4.033

7.  Evidence that insertion of Tomato ringspot nepovirus NTB-VPg protein in endoplasmic reticulum membranes is directed by two domains: a C-terminal transmembrane helix and an N-terminal amphipathic helix.

Authors:  Shuo Cheng Zhang; Guangzhi Zhang; Lanying Yang; Joan Chisholm; Hélène Sanfaçon
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

8.  Conformation and environment of channel-forming peptides: a simulation study.

Authors:  Jennifer M Johnston; Gabriel A Cook; John M Tomich; Mark S P Sansom
Journal:  Biophys J       Date:  2005-12-30       Impact factor: 4.033

9.  Complete predicted three-dimensional structure of the facilitator transmembrane protein and hepatitis C virus receptor CD81: conserved and variable structural domains in the tetraspanin superfamily.

Authors:  Michel Seigneuret
Journal:  Biophys J       Date:  2006-01-01       Impact factor: 4.033

10.  Scaling and alpha-helix regulation of protein relaxation in a lipid bilayer.

Authors:  Liming Qiu; Creighton Buie; Kwan Hon Cheng; Mark W Vaughn
Journal:  J Chem Phys       Date:  2014-12-14       Impact factor: 3.488
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