Literature DB >> 1294693

Phospholipase A2 inhibitors from marine organisms.

B C Potts1, D J Faulkner, R S Jacobs.   

Abstract

This review of phospholipase A2 (PLA2) inhibitors from marine organisms presents a compilation of research in this field over the past decade. As an introduction to the research on marine natural products, there is an overview of the role of PLA2 in inflammation that provides a rationale for seeking inhibitors of PLA2 as anti-inflammatory agents. A radiometric assay to measure inhibition of bee venom PLA2 is described in detail. Examples of marine natural products that inhibit PLA2 are manoalide and its derivatives, scalaradial and related compounds, the pseudopterosins, the vidalols, and a group of terpenoids that contain masked 1,4-dicarbonyl moieties.

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Year:  1992        PMID： 1294693     DOI： 10.1021/np50090a001

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  18 in total

1.  Impact of selenium on the leukotriene B4 synthesis pathway during isoproterenol-induced myocardial infarction in experimental rats.

Authors:  Seema Panicker; S S Swathy; Febi John; Indira M
Journal:  Inflammation       Date:  2012-02       Impact factor: 4.092

Review 2.  Sesterterpenoids with Anticancer Activity.

Authors:  Antonio Evidente; Alexander Kornienko; Florence Lefranc; Alessio Cimmino; Ramesh Dasari; Marco Evidente; Véronique Mathieu; Robert Kiss
Journal:  Curr Med Chem       Date:  2015       Impact factor: 4.530

3.  Modulation of acute and chronic inflammatory processes by cacospongionolide B, a novel inhibitor of human synovial phospholipase A2.

Authors:  P García Pastor; S De Rosa; A De Giulio; M Payá; M J Alcaraz
Journal:  Br J Pharmacol       Date:  1999-01       Impact factor: 8.739

4.  Preparation of phenalenes and hydronaphthacenes through tandem alkyne Fischer-carbene complex coupling and inter- or intramolecular Diels-Alder reactions.

Authors:  Rajesh Kumar Patti; Shaofeng Duan; Zhipeng Wang; James W Herndon
Journal:  Tetrahedron Lett       Date:  2011-08-10       Impact factor: 2.415

5.  Inhibition of phospholipase A2 activities and some inflammatory responses by the marine product ircinin.

Authors:  R Cholbi; M L Ferrándiz; M C Terencio; S De Rosa; M J Alcaraz; M Payá
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-11       Impact factor: 3.000

6.  Quorum sensing antagonism from marine organisms.

Authors:  Mette Elena Skindersoe; Piers Ettinger-Epstein; Thomas Bovbjerg Rasmussen; Thomas Bjarnsholt; Rocky de Nys; Michael Givskov
Journal:  Mar Biotechnol (NY)       Date:  2007-10-20       Impact factor: 3.619

Review 7.  Bioactive sesterterpenes and triterpenes from marine sponges: occurrence and pharmacological significance.

Authors:  Sherif S Ebada; Wenhan Lin; Peter Proksch
Journal:  Mar Drugs       Date:  2010-02-23       Impact factor: 5.118

8.  Platelet aggregation inhibitors from Philippine marine invertebrate samples screened in a new microplate assay.

Authors:  Sheila Marie V Pimentel; Zenaida P Bojo; Amy V D Roberto; Jose Enrico H Lazaro; Gina C Mangalindan; Leila M Florentino; Pilar Lim-Navarro; Deniz Tasdemir; Chris M Ireland; Gisela P Concepcion
Journal:  Mar Biotechnol (NY)       Date:  2003 Jul-Aug       Impact factor: 3.619

9.  Comparison of the biological properties of several marine sponge-derived sesquiterpenoid quinones.

Authors:  Cherie A Motti; Marie-Lise Bourguet-Kondracki; Arlette Longeon; Jason R Doyle; Lyndon E Llewellyn; Dianne M Tapiolas; Ping Yin
Journal:  Molecules       Date:  2007-07-11       Impact factor: 4.411

10.  Anti-inflammatory effects of the gorgonian Pseudopterogorgia elisabethae collected at the Islands of Providencia and San Andrés (SW Caribbean).

Authors:  Hebelin Correa; Alba Lucia Valenzuela; Luis Fernando Ospina; Carmenza Duque
Journal:  J Inflamm (Lond)       Date:  2009-03-10       Impact factor: 4.981
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