Literature DB >> 12946643

NMR-based screening technologies.

Murray Coles1, Markus Heller, Horst Kessler.   

Abstract

NMR-based ligand screening is now an established field in its own right. In recent years, advances in both methodology and hardware have broadened its range of applications and pushed back practical limitations, leading to the growing importance of NMR screening as a tool in industrial drug research. An overview of new screening methods and applications is presented here, and ways in which NMR-screening is being used in cooperation with other screening techniques are discussed.

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Year:  2003        PMID: 12946643     DOI: 10.1016/s1359-6446(03)02796-x

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN: 1359-6446            Impact factor:   7.851


  10 in total

1.  (1)H, (15)N and (13)C backbone and side chain assignments of PSD-95 PDZ3 protein.

Authors:  Nkoli Ukpabi; Sudhir Sharma; Mark R Spaller; Pearl Tsang
Journal:  J Biomol NMR       Date:  2004-09       Impact factor: 2.835

2.  NMR-based exploration of the acceptor binding site of human blood group B galactosyltransferase with molecular fragments.

Authors:  Christoph Rademacher; Jens Landström; Nora Sindhuwinata; Monica M Palcic; Göran Widmalm; Thomas Peters
Journal:  Glycoconj J       Date:  2010-03-09       Impact factor: 2.916

Review 3.  High-Throughput Screening by Nuclear Magnetic Resonance (HTS by NMR) for the Identification of PPIs Antagonists.

Authors:  Bainan Wu; Elisa Barile; Surya K De; Jun Wei; Angela Purves; Maurizio Pellecchia
Journal:  Curr Top Med Chem       Date:  2015       Impact factor: 3.295

Review 4.  Perspectives on NMR in drug discovery: a technique comes of age.

Authors:  Maurizio Pellecchia; Ivano Bertini; David Cowburn; Claudio Dalvit; Ernest Giralt; Wolfgang Jahnke; Thomas L James; Steve W Homans; Horst Kessler; Claudio Luchinat; Bernd Meyer; Hartmut Oschkinat; Jeff Peng; Harald Schwalbe; Gregg Siegal
Journal:  Nat Rev Drug Discov       Date:  2008-09       Impact factor: 84.694

Review 5.  Biophysical characterization of recombinant proteins: a key to higher structural genomics success.

Authors:  Masoud Vedadi; Cheryl H Arrowsmith; Abdellah Allali-Hassani; Guillermo Senisterra; Gregory A Wasney
Journal:  J Struct Biol       Date:  2010-05-11       Impact factor: 2.867

Review 6.  High-field solution NMR spectroscopy as a tool for assessing protein interactions with small molecule ligands.

Authors:  Andria L Skinner; Jennifer S Laurence
Journal:  J Pharm Sci       Date:  2008-11       Impact factor: 3.534

7.  Estimating protein-ligand binding affinity using high-throughput screening by NMR.

Authors:  Matthew D Shortridge; David S Hage; Gerard S Harbison; Robert Powers
Journal:  J Comb Chem       Date:  2008-10-03

8.  Perspectives of biomolecular NMR in drug discovery: the blessing and curse of versatility.

Authors:  Wolfgang Jahnke
Journal:  J Biomol NMR       Date:  2007-08-15       Impact factor: 2.582

Review 9.  NMR-based approaches for the identification and optimization of inhibitors of protein-protein interactions.

Authors:  Elisa Barile; Maurizio Pellecchia
Journal:  Chem Rev       Date:  2014-04-08       Impact factor: 60.622

10.  Detection of dynamic substrate binding using MRI.

Authors:  Nirbhay N Yadav; Xing Yang; Yuguo Li; Wenbo Li; Guanshu Liu; Peter C M van Zijl
Journal:  Sci Rep       Date:  2017-08-31       Impact factor: 4.379

  10 in total

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