Electrocardiographic imaging of atrial and ventricular electrical activation.

Inverse electrocardiography has been developing for several years. By combining measurements obtained by electrocardiographic body surface mapping with three-dimensional anatomical data, one can non-invasively image the electrical activation sequence in the human heart. In this study, an imaging approach that uses a bidomain theory-based surface heart model was applied to single-beat data of atrial and ventricular activation. We found that for sinus and paced rhythms, the sites of early activation and the areas with late activation were estimated with sufficient accuracy. In particular, for focal arrhythmias, this model-based imaging approach might allow the guidance and evaluation of antiarrhythmic interventions, for instance, in case of catheter ablation or drug therapy.