Literature DB >> 12946105

Proinflammatory effects of exogenously administered IL-10 in experimental autoimmune orchitis.

Tetsushi Kaneko1, Masahiro Itoh, Yoichi Nakamura, Akira Iimura, Shogo Hayashi, Kodo Takahashi, Franca Stivala, Klaus Bendtzen, Ferdinando Nicoletti.   

Abstract

We studied the effects of exogenously administered recombinant murine interleukin (IL)-10 on the development of experimental autoimmune orchitis (EAO) in C3H/He mice. IL-10 significantly augments histological signs of EAO when administered for 6 consecutive days from days 15 to 20 after primary immunisations with testicular germ cells. These data demonstrate that IL-10, in addition to its well-known antiinflammatory property, also has proinflammatory functions capable of up-regulating testicular immunoinflammatory processes in vivo.

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Year:  2003        PMID： 12946105     DOI： 10.1016/s1043-4666(03)00103-0

Source DB:  PubMed          Journal:  Cytokine        ISSN： 1043-4666            Impact factor:   3.861


  4 in total

1.  Histopathology of the tubuli recti at the start of experimental autoimmune orchitis in mice.

Authors:  Munekazu Naito; Hayato Terayama; Shuichi Hirai; Ning Qu; Shinichi Kawata; Masahiro Itoh
Journal:  Med Mol Morphol       Date:  2009-12-24       Impact factor: 2.309

2.  In vitro and in vivo targeted delivery of IL-10 interfering RNA by JC virus-like particles.

Authors:  Meng-Ing Chou; Yu-Fan Hsieh; Meilin Wang; Jinghua Tsai Chang; Deching Chang; Moncef Zouali; Gregory J Tsay
Journal:  J Biomed Sci       Date:  2010-06-24       Impact factor: 8.410

3.  Effects on the local immunity in the testis by exposure to di-(2-ethylhexyl) phthalate (DEHP) in mice.

Authors:  Miyuki Kitaoka; Shuichi Hirai; Hayato Terayama; Munekazu Naito; Ning Qu; Naoyuki Hatayama; Hidenobu Miyaso; Yoshiharu Matsuno; Masatoshi Komiyama; Masahiro Itoh; Chisato Mori
Journal:  J Reprod Dev       Date:  2013-07-26       Impact factor: 2.214

4.  In Silico and In Vivo Analysis of IL37 in Multiple Sclerosis Reveals Its Probable Homeostatic Role on the Clinical Activity, Disability, and Treatment with Fingolimod.

Authors:  Eugenio Cavalli; Emanuela Mazzon; Maria Sofia Basile; Santa Mammana; Manuela Pennisi; Paolo Fagone; Reni Kalfin; Vanja Martinovic; Jovana Ivanovic; Marko Andabaka; Sarlota Mesaros; Tatjana Pekmezovic; Jelena Drulovic; Ferdinando Nicoletti; Maria Cristina Petralia
Journal:  Molecules       Date:  2019-12-19       Impact factor: 4.411
  4 in total

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