BACKGROUND: Multiple brain abscesses are serious neurological problems with high mortality and disabling morbidity. The frequency is rising as a result of AIDS and the increasing number of immunocompromised patients. CASE STUDY: A 59-year-old woman developed signs and symptoms of diffuse brain dysfunction including fever and neck stiffness. A brain CT scan demonstrated nine contrast-enhancing ring-shaped lesions. Analysis of the cerebrospinal fluid using PCR-technique revealed DNA of Fusobacterium nucleatum. Conservative treatment with antibiotics was successful. The patient recovered with only mild cognitive deficits. RESULTS: The experience of our patient and the review of the literature indicate that multiple brain abscesses due to Fusobacterium nucleatum are rare. The most probable source is oral infection. CONCLUSION: Multiple brain abscesses may be caused by Fusobacterium nucleatum. Cerebrospinal fluid analysis using PCR technique is helpful with diagnosis. Conservative management can be successful.
BACKGROUND: Multiple brain abscesses are serious neurological problems with high mortality and disabling morbidity. The frequency is rising as a result of AIDS and the increasing number of immunocompromised patients. CASE STUDY: A 59-year-old woman developed signs and symptoms of diffuse brain dysfunction including fever and neck stiffness. A brain CT scan demonstrated nine contrast-enhancing ring-shaped lesions. Analysis of the cerebrospinal fluid using PCR-technique revealed DNA of Fusobacterium nucleatum. Conservative treatment with antibiotics was successful. The patient recovered with only mild cognitive deficits. RESULTS: The experience of our patient and the review of the literature indicate that multiple brain abscesses due to Fusobacterium nucleatum are rare. The most probable source is oral infection. CONCLUSION: Multiple brain abscesses may be caused by Fusobacterium nucleatum. Cerebrospinal fluid analysis using PCR technique is helpful with diagnosis. Conservative management can be successful.
Authors: H Nishi; N Hosomi; K Ohta; S Aoki; M Nakamori; T Nezu; H Shigeishi; T Shintani; T Obayashi; K Ishikawa; N Kinoshita; Y Shiga; M Sugiyama; H Ohge; H Maruyama; H Kawaguchi; H Kurihara Journal: Clin Exp Immunol Date: 2020-03-24 Impact factor: 4.330
Authors: Gunnar T R Hischebeth; Vera C Keil; Katrin Gentil; Azize Boström; Klaus Kuchelmeister; Isabelle Bekeredjian-Ding Journal: BMC Res Notes Date: 2014-06-10
Authors: Michael A Casasanta; Christopher C Yoo; Hans B Smith; Alison J Duncan; Kyla Cochrane; Ann C Varano; Emma Allen-Vercoe; Daniel J Slade Journal: J Biol Chem Date: 2017-10-11 Impact factor: 5.157