| Literature DB >> 12945776 |
Johny Wehbe1, Tarek Kassem, Valérie Rolland, Marc Rolland, Mohamad Tabcheh, Marie-Louise Roumestant, Jean Martinez.
Abstract
A short asymmetric synthesis of optically pure beta-substituted beta-hydroxy aspartates is described. The key step is an aldol reaction between a glycine enolate derived from an oxazinone intermediate used as chiral auxiliary and various alpha-keto esters. Excellent diastereomeric excesses are obtained.Entities:
Mesh：
Substances：
Year: 2003 PMID： 12945776 DOI： 10.1039/b212538b
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876