BACKGROUND: It is not clear whether risk factors for local recurrence after breast-conserving surgery differ in women having surgery for in situ or invasive cancer. Furthermore, the Nottingham Prognostic Index (NPI) and Nottingham Histological Grade (NHG) have been little studied as determinants of local recurrence risk. METHOD: In a case-control study (491 cases and 1098 controls) nested within a cohort of 7502 women who had surgery for in situ or invasive cancer of the breast, patient characteristics, tumour characteristics and treatment-related variables were evaluated as risk factors for local recurrence. RESULTS: Multivariate conditional logistic regression analyses showed that age below 40 years, tumour multicentricity and an unclear or unknown surgical margin were significant risk factors for local recurrence. Radiotherapy to the breast and adjuvant hormone therapy were protective. Cancer in situ was not associated with a higher risk of local recurrence than invasive cancer (odds ratio 1.0, 95 per cent confidence interval 0.8 to 1.3). NHG and NPI were not helpful in determining risk of local recurrence. CONCLUSION: Margin status, age, tumour multicentricity, and use of radiotherapy and adjuvant hormone therapy were important determinants of risk of local recurrence. With the exception of surgical margin, variables related to the quality of surgical management did not predict risk of local recurrence. Copyright 2003 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
BACKGROUND: It is not clear whether risk factors for local recurrence after breast-conserving surgery differ in women having surgery for in situ or invasive cancer. Furthermore, the Nottingham Prognostic Index (NPI) and Nottingham Histological Grade (NHG) have been little studied as determinants of local recurrence risk. METHOD: In a case-control study (491 cases and 1098 controls) nested within a cohort of 7502 women who had surgery for in situ or invasive cancer of the breast, patient characteristics, tumour characteristics and treatment-related variables were evaluated as risk factors for local recurrence. RESULTS: Multivariate conditional logistic regression analyses showed that age below 40 years, tumour multicentricity and an unclear or unknown surgical margin were significant risk factors for local recurrence. Radiotherapy to the breast and adjuvant hormone therapy were protective. Cancer in situ was not associated with a higher risk of local recurrence than invasive cancer (odds ratio 1.0, 95 per cent confidence interval 0.8 to 1.3). NHG and NPI were not helpful in determining risk of local recurrence. CONCLUSION: Margin status, age, tumour multicentricity, and use of radiotherapy and adjuvant hormone therapy were important determinants of risk of local recurrence. With the exception of surgical margin, variables related to the quality of surgical management did not predict risk of local recurrence. Copyright 2003 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Authors: Siong-Seng Liau; Massimiliano Cariati; David Noble; Charles Wilson; Gordon C Wishart Journal: Ann R Coll Surg Engl Date: 2010-06-01 Impact factor: 1.891
Authors: Martina Meier-Meitinger; Lothar Häberle; Peter A Fasching; Mayada R Bani; Katharina Heusinger; David Wachter; Matthias W Beckmann; Michael Uder; Rüdiger Schulz-Wendtland; Boris Adamietz Journal: Eur Radiol Date: 2010-12-30 Impact factor: 5.315
Authors: Woo Chul Noh; Nam Sun Paik; Min Suk Kim; Kwang Mo Yang; Chul Koo Cho; Dong Wook Choi; Jong Inn Lee; Sung Ku Kang; Sang Bum Kim; Nan Mo Moon Journal: World J Surg Date: 2005-08 Impact factor: 3.352
Authors: Dung-Tsa Chen; Aejaz Nasir; Aedin Culhane; Chinnambally Venkataramu; William Fulp; Renee Rubio; Tao Wang; Deepak Agrawal; Susan M McCarthy; Mike Gruidl; Gregory Bloom; Tove Anderson; Joe White; John Quackenbush; Timothy Yeatman Journal: Breast Cancer Res Treat Date: 2009-03-06 Impact factor: 4.872
Authors: Hanna Fredholm; Sonja Eaker; Jan Frisell; Lars Holmberg; Irma Fredriksson; Henrik Lindman Journal: PLoS One Date: 2009-11-11 Impact factor: 3.240