BACKGROUND: Bilaterality in breast cancer is a rare event and together with an early onset of disease points towards inheritance of the disease. However, most cases seem to occur sporadically, either in a synchronous or metachronous manner. METHODS: Thirty two invasive carcinomas and one in situ carcinoma from 16 patients with synchronous, bilateral breast cancer were investigated by means of comparative genomic hybridisation (CGH) and polymerase chain reaction based multiplex microsatellite analysis. The results were analysed conventionally and were also subjected to a biomathematical cluster analysis. RESULTS: On average, bilateral breast cancer cases showed a low number of genetic alterations, a low frequency of genetic amplifications, and a high rate of chromosomal 16q losses. A distinct, characteristic genetic alteration associated with bilateral breast disease could not be found. Although two tumour pairs appeared to be related using biomathematical processing for microsatellite analysis, this result was reproduced by CGH data processing in one patient only. CONCLUSIONS: Most synchronous, bilateral breast cancer cases seem to represent independent tumours rather than metastatic events. Nevertheless, the possibility of a specific susceptibility remains.
BACKGROUND: Bilaterality in breast cancer is a rare event and together with an early onset of disease points towards inheritance of the disease. However, most cases seem to occur sporadically, either in a synchronous or metachronous manner. METHODS: Thirty two invasive carcinomas and one in situ carcinoma from 16 patients with synchronous, bilateral breast cancer were investigated by means of comparative genomic hybridisation (CGH) and polymerase chain reaction based multiplex microsatellite analysis. The results were analysed conventionally and were also subjected to a biomathematical cluster analysis. RESULTS: On average, bilateral breast cancer cases showed a low number of genetic alterations, a low frequency of genetic amplifications, and a high rate of chromosomal 16q losses. A distinct, characteristic genetic alteration associated with bilateral breast disease could not be found. Although two tumour pairs appeared to be related using biomathematical processing for microsatellite analysis, this result was reproduced by CGH data processing in one patient only. CONCLUSIONS: Most synchronous, bilateral breast cancer cases seem to represent independent tumours rather than metastatic events. Nevertheless, the possibility of a specific susceptibility remains.
Authors: H Buerger; F Gebhardt; H Schmidt; A Beckmann; K Hutmacher; R Simon; R Lelle; W Boecker; B Brandt Journal: Cancer Res Date: 2000-02-15 Impact factor: 12.701
Authors: H Buerger; F Otterbach; R Simon; K L Schäfer; C Poremba; R Diallo; C Brinkschmidt; B Dockhorn-Dworniczak; W Boecker Journal: J Pathol Date: 1999-12 Impact factor: 7.996
Authors: J M Garcia; J M Silva; G Dominguez; R Gonzalez; A Navarro; L Carretero; M Provencio; P España; F Bonilla Journal: Breast Cancer Res Treat Date: 1999-10 Impact factor: 4.872
Authors: H Buerger; F Otterbach; R Simon; C Poremba; R Diallo; T Decker; L Riethdorf; C Brinkschmidt; B Dockhorn-Dworniczak; W Boecker Journal: J Pathol Date: 1999-03 Impact factor: 7.996
Authors: J Kollias; S Man; M Marafie; K Carpenter; S Pinder; I O Ellis; R W Blamey; G Cross; J D Brook Journal: Breast Cancer Res Treat Date: 2000-12 Impact factor: 4.872
Authors: E N Imyanitov; A V Togo; E N Suspitsin; M Y Grigoriev; K M Pozharisski; E A Turkevich; K P Hanson; N K Hayward; G Chenevix-Trench; C Theillet; M F Lavin Journal: Cancer Lett Date: 2000-06-01 Impact factor: 8.679
Authors: Irina Ostrovnaya; Adam B Olshen; Venkatraman E Seshan; Irene Orlow; Donna G Albertson; Colin B Begg Journal: Stat Med Date: 2010-07-10 Impact factor: 2.373
Authors: Yaning Zhao; N A Yuan; Kuanzhi Li; Y I Geng; Haiping Zhou; Hua Wang; Jie Hou; Bin Zhang; Yuan Cai; Xinhan Zhao Journal: Oncol Lett Date: 2015-04-14 Impact factor: 2.967
Authors: Nicolas Girard; Irina Ostrovnaya; Christopher Lau; Bernard Park; Marc Ladanyi; David Finley; Charuhas Deshpande; Valerie Rusch; Irene Orlow; William D Travis; William Pao; Colin B Begg Journal: Clin Cancer Res Date: 2009-08-11 Impact factor: 12.531
Authors: Raj Chari; Kelsie L Thu; Ian M Wilson; William W Lockwood; Kim M Lonergan; Bradley P Coe; Chad A Malloff; Adi F Gazdar; Stephen Lam; Cathie Garnis; Calum E MacAulay; Carlos E Alvarez; Wan L Lam Journal: Cancer Metastasis Rev Date: 2010-03 Impact factor: 9.264
Authors: Arezou A Ghazani; Nona Arneson; Keisha Warren; Melania Pintilie; Jane Bayani; Jeremy A Squire; Susan J Done Journal: Neoplasia Date: 2007-06 Impact factor: 5.715