Literature DB >> 12943856

The enzyme as drug: application of enzymes as pharmaceuticals.

Michel Vellard1.   

Abstract

Enzymes as drugs have two important features that distinguish them from all other types of drugs. First, enzymes often bind and act on their targets with great affinity and specificity. Second, enzymes are catalytic and convert multiple target molecules to the desired products. These two features make enzymes specific and potent drugs that can accomplish therapeutic biochemistry in the body that small molecules cannot. These characteristics have resulted in the development of many enzyme drugs for a wide range of disorders.

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Year:  2003        PMID: 12943856     DOI: 10.1016/s0958-1669(03)00092-2

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN: 0958-1669            Impact factor:   9.740


  43 in total

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6.  In vivo fluorescence imaging of exogenous enzyme activity in the gastrointestinal tract.

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Review 7.  High performance affinity chromatography and related separation methods for the analysis of biological and pharmaceutical agents.

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8.  Engineering of Nanoscale Coordination Polymers with Biomolecules for Advanced Applications.

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Review 9.  Arginine depriving enzymes: applications as emerging therapeutics in cancer treatment.

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Journal:  Cancer Chemother Pharmacol       Date:  2021-07-26       Impact factor: 3.333

10.  In vivo administration of BL-3050: highly stable engineered PON1-HDL complexes.

Authors:  Leonid Gaidukov; Dganit Bar; Shiri Yacobson; Esmira Naftali; Olga Kaufman; Rinat Tabakman; Dan S Tawfik; Etgar Levy-Nissenbaum
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