D M Smith1, G P Raaphorst. 1. Centre Hospitalier des Vallees de l'Outaouais, 909 Blvd. de la Vérendrye Ouest, Gatineau, Québec, Canada J8P 7H2.
Abstract
PURPOSE: Human gliomas are known to be radioresistant and the aim was to determine if this resistance in part could be due to an adaptive response. MATERIALS AND METHODS: Human U-87MG glioma cells were used. Three different radiation regimens that could be related to clinical treatments were tested for their ability to cause an adaptive response. Cell survival and DNA double-strand breakage were the measured endpoints. RESULTS: All three regimens caused an adaptive response in terms of cell survival when given priming doses of radiation. The DNA double-strand break endpoint also showed fewer breaks when the adaptive response occurred. CONCLUSIONS: Using irradiation regimens that closely resembled clinical applications, in vitro data are presented that show an adaptive response in human glioma cells. This effect in part could be responsible for the radioresistance of human gliomas.
PURPOSE:Humangliomas are known to be radioresistant and the aim was to determine if this resistance in part could be due to an adaptive response. MATERIALS AND METHODS:Human U-87MG glioma cells were used. Three different radiation regimens that could be related to clinical treatments were tested for their ability to cause an adaptive response. Cell survival and DNA double-strand breakage were the measured endpoints. RESULTS: All three regimens caused an adaptive response in terms of cell survival when given priming doses of radiation. The DNA double-strand break endpoint also showed fewer breaks when the adaptive response occurred. CONCLUSIONS: Using irradiation regimens that closely resembled clinical applications, in vitro data are presented that show an adaptive response in humanglioma cells. This effect in part could be responsible for the radioresistance of humangliomas.
Authors: Margaret S Lee; Mina Yaar; Mark S Eller; Thomas M Rünger; Ying Gao; Barbara A Gilchrest Journal: J Dermatol Sci Date: 2009-11-10 Impact factor: 4.563
Authors: Giovanni Borasi; Alan Nahum; Margarethus M Paulides; Gibin Powathil; Giorgio Russo; Laura Fariselli; Debora Lamia; Roberta Cirincione; Giusi Irma Forte; Cristian Borrazzo; Barbara Caccia; Elisabetta di Castro; Silvia Pozzi; Maria Carla Gilardi Journal: J Ther Ultrasound Date: 2016-12-08