Literature DB >> 12943226

The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses.

C P Bracken1, M L Whitelaw, D J Peet.   

Abstract

Oxygen depravation in mammals leads to the transcriptional induction of a host of target genes to metabolically adapt to this deficiency, including erythropoietin and vascular endothelial growth factor. This response is primarily mediated by the hypoxia-inducible factors (HIFs) which are members of the basic-helix-loop-helix/Per-ARNT-Sim (bHLH/PAS) transcription factor family. The HIFs are primarily regulated via a two-step mechanism of HIF post-translational modification, increasing both protein stability and transactivation capacity. This review aims to summarise our current understanding of these processes, and discuss the important role of the HIFs in the pathophysiology of many human diseases.

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Year:  2003        PMID： 12943226     DOI： 10.1007/s00018-003-2370-y

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  62 in total

Review 1.  Hypoxia-inducible factors regulate T cell metabolism and function.

Authors:  Anthony T Phan; Ananda W Goldrath
Journal:  Mol Immunol       Date:  2015-08-19       Impact factor: 4.407

2.  Hypoxia activates constitutive luciferase reporter constructs.

Authors:  Diane M Doran; Kashmira Kulkarni-Datar; David R Cool; Thomas L Brown
Journal:  Biochimie       Date:  2010-10-26       Impact factor: 4.079

3.  Concerted inhibition of HIF-1α and -2α expression markedly suppresses angiogenesis in cultured RPE cells.

Authors:  Takeshi Nakajima; Emi Nakajima; Thomas R Shearer; Mitsuyoshi Azuma
Journal:  Mol Cell Biochem       Date:  2013-07-20       Impact factor: 3.396

Review 4.  Excitation-transcription coupling in skeletal muscle: the molecular pathways of exercise.

Authors:  Kristian Gundersen
Journal:  Biol Rev Camb Philos Soc       Date:  2010-10-06

5.  Activation of CaMKIIδA promotes Ca2+ leak from the sarcoplasmic reticulum in cardiomyocytes of chronic heart failure rats.

Authors:  Le Gui; Xin Guo; Zhe Zhang; Hui Xu; Ya-Wei Ji; Ren-Jun Wang; Jiang-Hua Zhu; Qing-Hui Chen
Journal:  Acta Pharmacol Sin       Date:  2018-06-14       Impact factor: 6.150

6.  Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB.

Authors:  Stilla Frede; Christian Stockmann; Patricia Freitag; Joachim Fandrey
Journal:  Biochem J       Date:  2006-06-15       Impact factor: 3.857

7.  Gene expression microarray analysis of early oxygen-induced retinopathy in the rat.

Authors:  Melinda Tea; Rhys Fogarty; Helen M Brereton; Michael Z Michael; Mark B Van der Hoek; Anna Tsykin; Douglas J Coster; Keryn A Williams
Journal:  J Ocul Biol Dis Infor       Date:  2009-12-12

8.  HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression.

Authors:  Jacqueline Kessler; Antje Hahnel; Henri Wichmann; Swetlana Rot; Matthias Kappler; Matthias Bache; Dirk Vordermark
Journal:  BMC Cancer       Date:  2010-11-04       Impact factor: 4.430

9.  Congenital erythrocytosis associated with gain-of-function HIF2A gene mutations and erythropoietin levels in the normal range.

Authors:  Silverio Perrotta; Daniel P Stiehl; Francesca Punzo; Saverio Scianguetta; Adriana Borriello; Debora Bencivenga; Maddalena Casale; Bruno Nobili; Silvia Fasoli; Adriana Balduzzi; Lilla Cro; Katarzyna J Nytko; Roland H Wenger; Fulvio Della Ragione
Journal:  Haematologica       Date:  2013-05-28       Impact factor: 9.941

Review 10.  RNA-binding proteins implicated in the hypoxic response.

Authors:  Kiyoshi Masuda; Kotb Abdelmohsen; Myriam Gorospe
Journal:  J Cell Mol Med       Date:  2009-07-06       Impact factor: 5.310
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