[Development of adrenal chromaffin tissue].

The purpose of the present investigation was to study the morphological peculiarities of chromaffinoblasts and to determine their interrelations with the surrounding cellular elements of the fetal cortex at the early stages (embryonic weeks 4-7) of their migration into the developing adrenal gland of a pig. At week 5 neuro-cellular cords, consisting of so-called "naked" axons, neuroblasts, lemmoblasts, undifferentiated cells, chromaffinoblast clusters and chromaffinocytes, grow into the fetal cortex from side of abdominal aorta. In fetal cortex parenchyma chromaffin elements form cords, lobes, "medullary globes", which are enveloped by a basal membrane, which is a derivative of satellitocytes. Chromaffinocytes are stained with Wood's stain, potassium bichromate and, judging by the presence of secretory granules in their cytoplasm, are capable to synthesize summary catecholamines and to release them into the blood at the early stages of development. "Medullary globes" are the centers of proliferation and differentiation of the chromaffin cells in the adrenal medulla. The problem of chromaffin tissue stem cells is discussed.