| Literature DB >> 12941335 |
Yihan Wang1, Chester A Metcalf, William C Shakespeare, Raji Sundaramoorthi, Terence P Keenan, Regine S Bohacek, Marie Rose van Schravendijk, Shiela M Violette, Surinder S Narula, David C Dalgarno, Chad Haraldson, Jeffrey Keats, Shuenn Liou, Ukti Mani, Selvi Pradeepan, Mary Ram, Susan Adams, Manfred Weigele, Tomi K Sawyer.
Abstract
Novel bone-targeted 2,6,9-trisubstituted purine template-based inhibitors of Src tyrosine kinase are described. Drug design studies of known purine compounds revealed that both positions-2 and -6 were suitable for incorporating bone-seeking moieties. A variety of bone-targeting groups with different affinity to hydroxyapatite were utilized in the study. Compound 3d was determined to be a potent Src inhibitor and was quite selective against a panel of other protein kinases.Entities:
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Year: 2003 PMID： 12941335 DOI： 10.1016/s0960-894x(03)00648-6
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823