Literature DB >> 12941333

6-heteroaryl-pyrazolo[3,4-b]pyridines: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).

Jason Witherington1, Vincent Bordas, Alessandra Gaiba, Antoinette Naylor, Anthony D Rawlings, Brian P Slingsby, David G Smith, Andrew K Takle, Robert W Ward.   

Abstract

A series of 6-heteroaryl-pyrazolo[3,4-b]pyridines has been optimised to afford potent inhibitors of Glycogen Synthase Kinase-3 (GSK-3). These analogues display excellent selectivity over the closely related Cyclin Dependent Kinase-2 (CDK-2).

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12941333     DOI： 10.1016/s0960-894x(03)00646-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  New leads for selective GSK-3 inhibition: pharmacophore mapping and virtual screening studies.

Authors:  Dhilon S Patel; Prasad V Bharatam
Journal:  J Comput Aided Mol Des       Date:  2006-04-19       Impact factor: 3.686

2.  Construction of pyrazolo[3,4-b]pyridines and pyrazolo[4,3-c]pyridines by ring closure of 3-acylpyridine N-oxide tosylhydrazones.

Authors:  William J Lominac; Megan L D'Angelo; Mark D Smith; Darius A Ollison; James M Hanna
Journal:  Tetrahedron Lett       Date:  2012-02-22       Impact factor: 2.415

Review 3.  Amyloid beta modulators and neuroprotection in Alzheimer's disease: a critical appraisal.

Authors:  Chandra Sekhar Kuruva; P Hemachandra Reddy
Journal:  Drug Discov Today       Date:  2016-10-27       Impact factor: 7.851

4.  Surface Plasmon Resonance Screening to Identify Active and Selective Adenosine Receptor Binding Fragments.

Authors:  Claire Shepherd; Sean Robinson; Alice Berizzi; Laura E J Thompson; Louise Bird; Simone Culurgioni; Simon Varzandeh; Philip B Rawlins; Reid H J Olsen; Iva Hopkins Navratilova
Journal:  ACS Med Chem Lett       Date:  2022-06-06       Impact factor: 4.632

5.  Use of molecular modeling, docking, and 3D-QSAR studies for the determination of the binding mode of benzofuran-3-yl-(indol-3-yl)maleimides as GSK-3beta inhibitors.

Authors:  Ki Hwan Kim; Irina Gaisina; Franck Gallier; Denise Holzle; Sylvie Y Blond; Andrew Mesecar; Alan P Kozikowski
Journal:  J Mol Model       Date:  2009-05-14       Impact factor: 1.810

6.  Glycogen synthase kinase-3 inhibition by 3-anilino-4-phenylmaleimides: insights from 3D-QSAR and docking.

Authors:  Sivaprakasam Prasanna; Pankaj R Daga; Aihua Xie; Robert J Doerksen
Journal:  J Comput Aided Mol Des       Date:  2008-10-07       Impact factor: 3.686

7.  The Suzuki reaction applied to the synthesis of novel pyrrolyl and thiophenyl indazoles.

Authors:  Antonella Migliorini; Chiara Oliviero; Tecla Gasperi; Maria Antonietta Loreto
Journal:  Molecules       Date:  2012-04-16       Impact factor: 4.411

8.  Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models.

Authors:  Thomas Kramer; Boris Schmidt; Fabio Lo Monte
Journal:  Int J Alzheimers Dis       Date:  2012-07-22

9.  Synthesis and antimicrobial evaluation of some novel bis-α,β-unsaturated ketones, nicotinonitrile, 1,2-dihydropyridine-3-carbonitrile, fused thieno[2,3-b]pyridine and pyrazolo[3,4-b]pyridine derivatives.

Authors:  Farag M A Altalbawy
Journal:  Int J Mol Sci       Date:  2013-01-30       Impact factor: 5.923

10.  Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3.

Authors:  M Lourdes Sciú; Victor Sebastián-Pérez; Loreto Martinez-Gonzalez; Rocio Benitez; Daniel I Perez; Concepción Pérez; Nuria E Campillo; Ana Martinez; E Laura Moyano
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.