Literature DB >> 12941332

6-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

Jason Witherington1, Vincent Bordas, Alessandra Gaiba, Neil S Garton, Antoinette Naylor, Anthony D Rawlings, Brian P Slingsby, David G Smith, Andrew K Takle, Robert W Ward.   

Abstract

A novel series of 6-aryl-pyrazolo[3,4-b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3).

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Year:  2003        PMID： 12941332     DOI： 10.1016/s0960-894x(03)00645-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

1.  Construction of pyrazolo[3,4-b]pyridines and pyrazolo[4,3-c]pyridines by ring closure of 3-acylpyridine N-oxide tosylhydrazones.

Authors:  William J Lominac; Megan L D'Angelo; Mark D Smith; Darius A Ollison; James M Hanna
Journal:  Tetrahedron Lett       Date:  2012-02-22       Impact factor: 2.415

2.  Four-component strategy for selective synthesis of azepino[5,4,3-cd]indoles and pyrazolo[3,4-b]pyridines.

Authors:  Bo Jiang; Qin Ye; Wei Fan; Shu-Liang Wang; Shu-Jiang Tu; Guigen Li
Journal:  Chem Commun (Camb)       Date:  2014-06-11       Impact factor: 6.222

3.  Use of molecular modeling, docking, and 3D-QSAR studies for the determination of the binding mode of benzofuran-3-yl-(indol-3-yl)maleimides as GSK-3beta inhibitors.

Authors:  Ki Hwan Kim; Irina Gaisina; Franck Gallier; Denise Holzle; Sylvie Y Blond; Andrew Mesecar; Alan P Kozikowski
Journal:  J Mol Model       Date:  2009-05-14       Impact factor: 1.810

4.  Glycogen synthase kinase-3 inhibition by 3-anilino-4-phenylmaleimides: insights from 3D-QSAR and docking.

Authors:  Sivaprakasam Prasanna; Pankaj R Daga; Aihua Xie; Robert J Doerksen
Journal:  J Comput Aided Mol Des       Date:  2008-10-07       Impact factor: 3.686

Review 5.  Glycogen synthase kinase 3: more than a namesake.

Authors:  Geetha Vani Rayasam; Vamshi Krishna Tulasi; Reena Sodhi; Joseph Alex Davis; Abhijit Ray
Journal:  Br J Pharmacol       Date:  2009-03-04       Impact factor: 8.739

6.  From PIM1 to PI3Kδ via GSK3β: Target Hopping through the Kinome.

Authors:  Zoë A Henley; Benjamin D Bax; Laura M Inglesby; Aurélie Champigny; Simon Gaines; Paul Faulder; Joelle Le; Daniel A Thomas; Yoshiaki Washio; Ian R Baldwin
Journal:  ACS Med Chem Lett       Date:  2017-09-07       Impact factor: 4.345

7.  5-(4-Chloro-phen-yl)-1-methyl-3-phenyl-3,6,8,9-tetra-hydro-pyrazolo-[3,4-b]thio-pyrano[4,3-d]pyridine.

Authors:  Runhong Jia; Juhua Peng
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-08-27

8.  Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models.

Authors:  Thomas Kramer; Boris Schmidt; Fabio Lo Monte
Journal:  Int J Alzheimers Dis       Date:  2012-07-22

9.  Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays.

Authors:  Patricia Dranchak; Ryan MacArthur; Rajarshi Guha; William J Zuercher; David H Drewry; Douglas S Auld; James Inglese
Journal:  PLoS One       Date:  2013-03-07       Impact factor: 3.240

10.  Ionic liquid-promoted multi-component reaction: novel and efficient preparation of pyrazolo[3,4-b]pyridinone, pyrazolo[3,4-b]-quinolinone and their hybrids with pyrimidine nucleoside.

Authors:  Xinying Zhang; Dongfang Li; Xuesen Fan; Xia Wang; Xiaoyan Li; Guirong Qu; Jianji Wang
Journal:  Mol Divers       Date:  2009-06-12       Impact factor: 3.364
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