Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

Literature DB >> 12941330

Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

Veerle Vanheusden¹, Philippe Van Rompaey, Hélène Munier-Lehmann, Sylvie Pochet, Piet Herdewijn, Serge Van Calenbergh.

Abstract

The affinity of a series of 2', 3'- and 5-modified thymidine analogues for Mycobacterium tuberculosis thymidine monophosphate kinase (TMPKmt) was evaluated. The affinities of several non-phosphorylated analogues are in the same order of magnitude as those of their phosphorylated congeners. In view of drug delivery problems associated with phosphorylated compounds, these 'free' nucleosides seem more promising leads in the search of TMPKmt inhibitors as novel anti-tuberculosis agents.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2003 PMID： 12941330 DOI： 10.1016/s0960-894x(03)00643-7

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

Keyword Cloud
Cited

10 in total

1. Mechanisms of substrate selectivity for Bacillus anthracis thymidylate kinase.

Authors: Cecilia Carnrot; Liya Wang; Dimitri Topalis; Staffan Eriksson
Journal: Protein Sci Date: 2008-06-03 Impact factor: 6.725

2. 3D-Pharmacophore mapping of thymidine-based inhibitors of TMPK as potential antituberculosis agents.

Authors: Carolina Horta Andrade; Kerly F M Pasqualoto; Elizabeth I Ferreira; Anton J Hopfinger
Journal: J Comput Aided Mol Des Date: 2010-03-10 Impact factor: 3.686

3. Structural and chemical basis for enhanced affinity to a series of mycobacterial thymidine monophosphate kinase inhibitors: fragment-based QSAR and QM/MM docking studies.

Authors: Renata V Bueno; Ney R Toledo; Bruno J Neves; Rodolpho C Braga; Carolina H Andrade
Journal: J Mol Model Date: 2012-07-31 Impact factor: 1.810

4. Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation.

Authors: Jun Yong Choi; Mark S Plummer; Jeremy Starr; Charlene R Desbonnet; Holly Soutter; Jeanne Chang; J Richard Miller; Keith Dillman; Alita A Miller; William R Roush
Journal: J Med Chem Date: 2012-01-13 Impact factor: 7.446

5. Computer-assisted combinatorial design of bicyclic thymidine analogs as inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

Authors: Vladimir Frecer; Pierfausto Seneci; Stanislav Miertus
Journal: J Comput Aided Mol Des Date: 2010-11-17 Impact factor: 3.686

6. Structure-based in-silico rational design of a selective peptide inhibitor for thymidine monophosphate kinase of mycobacterium tuberculosis.

Authors: Manoj Kumar; Sujata Sharma; Alagiri Srinivasan; Tej P Singh; Punit Kaur
Journal: J Mol Model Date: 2010-08-11 Impact factor: 1.810

Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

1. Mechanisms of substrate selectivity for Bacillus anthracis thymidylate kinase.

2. 3D-Pharmacophore mapping of thymidine-based inhibitors of TMPK as potential antituberculosis agents.

3. Structural and chemical basis for enhanced affinity to a series of mycobacterial thymidine monophosphate kinase inhibitors: fragment-based QSAR and QM/MM docking studies.

4. Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation.

5. Computer-assisted combinatorial design of bicyclic thymidine analogs as inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

6. Structure-based in-silico rational design of a selective peptide inhibitor for thymidine monophosphate kinase of mycobacterium tuberculosis.

7. RepTB: a gene ontology based drug repurposing approach for tuberculosis.

8. 1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors.

9. Design of Thymidine Analogues Targeting Thymidilate Kinase of Mycobacterium tuberculosis.

10. Chemotherapeutic interventions against tuberculosis.