Literature DB >> 12941315

Inhibition of Src kinase activity by 4-anilino-5,10-dihydro-pyrimido[4,5-b]quinolines.

Diane H Boschelli1, Dennis Powell, Jennifer M Golas, Frank Boschelli.   

Abstract

4-(2,4-Dichloro-5-methoxy)anilino-5,10-dihydropyrimido[4,5-b]quinolines are potent inhibitors of Src kinase and Src cellular activity while having no effect on Fyn cellular activity. The corresponding 4-(2,4-dichloro-5-methoxy)anilino-pyrimido[4,5-b]quinolines are much less effective Src inhibitors.

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Year:  2003        PMID： 12941315     DOI： 10.1016/s0960-894x(03)00628-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

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2.  Synthesis, crystal structure and in silico studies of novel 2,4-dimethoxy-tetrahydropyrimido[4,5-b]quinolin-6(7H)-ones.

Authors:  Subham G Patel; Ruturajsinh M Vala; Paras J Patel; Dipti B Upadhyay; V Ramkumar; Ramesh L Gardas; Hitendra M Patel
Journal:  RSC Adv       Date:  2022-06-29       Impact factor: 4.036

3.  In vitro and in vivo identification of ABCB1 as an efflux transporter of bosutinib.

Authors:  Sara Redaelli; Pietro Perini; Monica Ceccon; Rocco Piazza; Roberta Rigolio; Mario Mauri; Frank Boschelli; Athina Giannoudis; Carlo Gambacorti-Passerini
Journal:  J Hematol Oncol       Date:  2015-07-07       Impact factor: 17.388
  3 in total

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