BACKGROUND: Remodeling is considered a new or different reconstruction of tissues. The airway remodeling is a consequence of changes induced by endothelial cells and extra-cellular matrix as a result of chronic inflammation. OBJECTIVE: To show histological changes into mucosa in patients with perennial allergic rhinitis. MATERIAL AND METHODS: We studied 26 patients with perennial allergic rhinitis, with evolution of 3 to 6 years, between 20 to 40 years old, without medical or immunological treatment. A turbinate biopsy was taken in all of them. RESULTS: We found enlargement of the basal membrane in 92.3%, subepithelial fibrosis in 92.4%, neutrophils in 100% of the cases, eosinophils in 100%, lymphocytes in 100%, edema in 46.2%, fragmented reticular fibers in 19.2%, and vascular dilatation in 11.1%. CONCLUSION: These results suggest nasal remodeling in patients with allergic rhinitis, although more structural studies about this pathology are necessary.
BACKGROUND: Remodeling is considered a new or different reconstruction of tissues. The airway remodeling is a consequence of changes induced by endothelial cells and extra-cellular matrix as a result of chronic inflammation. OBJECTIVE: To show histological changes into mucosa in patients with perennial allergic rhinitis. MATERIAL AND METHODS: We studied 26 patients with perennial allergic rhinitis, with evolution of 3 to 6 years, between 20 to 40 years old, without medical or immunological treatment. A turbinate biopsy was taken in all of them. RESULTS: We found enlargement of the basal membrane in 92.3%, subepithelial fibrosis in 92.4%, neutrophils in 100% of the cases, eosinophils in 100%, lymphocytes in 100%, edema in 46.2%, fragmented reticular fibers in 19.2%, and vascular dilatation in 11.1%. CONCLUSION: These results suggest nasal remodeling in patients with allergic rhinitis, although more structural studies about this pathology are necessary.
Authors: P Castelnuovo; G Tajana; P Terranova; E Digilio; M Bignami; Alberto Macchi Journal: Int J Immunopathol Pharmacol Date: 2015-04-21 Impact factor: 3.219
Authors: Fernando P Gaspar Sobrinho; Adelmir Souza-Machado; Alvaro A Cruz; Hélio A Lessa; Eduardo A Ramos Journal: Braz J Otorhinolaryngol Date: 2012-04