Literature DB >> 12939036

Immunomodulatory triterpenoids from the oleogum resin of Boswellia carterii Birdwood.

Farid A Badria1, Botros R Mikhaeil, Galal T Maatooq, Mohamed M A Amer.   

Abstract

The immunomodulatory bioassay-guided fractionation of the oleogum resin of frankincense (Boswellia carterii Birdwood) resulted in the isolation and identification of 9 compounds; palmitic acid and eight triterpenoids belonging to lupane, ursane, oleanane, and tirucallane skeleta were isolated form the resin. These triterpenoids are lupeol, beta-boswellic acid, 11-keto-beta-boswellic acid, acetyl beta-boswellic acid, acetyl 11-keto-beta-boswellic acid, acetyl-alpha-boswellic acid, 3-oxo-tirucallic acid, and 3-hydroxy-tirucallic acid. The structures of the isolated compounds were deduced based on spectroscopic evidences. The lymphocyte transformation assay of the isolated compounds proved that the total extract retained more activity than that of any of the purified compounds.

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Year:  2003        PMID: 12939036     DOI: 10.1515/znc-2003-7-811

Source DB:  PubMed          Journal:  Z Naturforsch C J Biosci        ISSN: 0341-0382


  14 in total

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Journal:  World J Gastroenterol       Date:  2012-02-21       Impact factor: 5.742

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Journal:  Inflammopharmacology       Date:  2019-08-12       Impact factor: 4.473

Review 4.  Active ingredients in Chinese medicines promoting blood circulation as Na+/K+ -ATPase inhibitors.

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5.  Gastroretentive Matrix Tablets of Boswellia Oleogum Resin: Preparation, Optimization, In Vitro Evaluation, and Cytoprotective Effect on Indomethacin-Induced Gastric Ulcer in Rabbits.

Authors:  Rehab Mohammad Yusif; Irhan Ibrahim Abu Hashim; Elham Abdelmonem Mohamed; Farid Abd-Elreheim Badria
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6.  Boswellic acids extract attenuates pulmonary fibrosis induced by bleomycin and oxidative stress from gamma irradiation in rats.

Authors:  Eman Noaman Ali; Somaya Zakaria Mansour
Journal:  Chin Med       Date:  2011-09-30       Impact factor: 5.455

7.  Antioxidant and Ex Vivo Immune System Regulatory Properties of Boswellia serrata Extracts.

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8.  Formulation of Nanospanlastics as a Promising Approach for ‎Improving the Topical Delivery of a Natural Leukotriene Inhibitor (3-‎Acetyl-11-Keto-β-Boswellic Acid): Statistical Optimization, in vitro ‎Characterization, and ex vivo Permeation Study.

Authors:  Farid Badria; Eman Mazyed
Journal:  Drug Des Devel Ther       Date:  2020-09-15       Impact factor: 4.162

Review 9.  Boswellic acids/Boswellia serrata extract as a potential COVID-19 therapeutic agent in the elderly.

Authors:  Adel A Gomaa; Hamdy S Mohamed; Rasha Bakheet Abd-Ellatief; Mohamed A Gomaa
Journal:  Inflammopharmacology       Date:  2021-07-05       Impact factor: 4.473

10.  Current status of herbal drugs in India: an overview.

Authors:  Ashok D B Vaidya; Thomas P A Devasagayam
Journal:  J Clin Biochem Nutr       Date:  2007-07       Impact factor: 3.114

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