Literature DB >> 1293868

How to estimate the total receptor concentration when the specific radioactivity of the ligand is unknown.

S Swillens1.   

Abstract

A computation method is presented allowing a direct determination of the total receptor concentration from a competitive displacement curve. Compared to the classical method based on the numerical processing of binding data, the proposed method has the advantage of being more accurate and of not requiring knowledge of the specific radioactivity of the ligand.

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Year:  1992        PMID： 1293868     DOI： 10.1016/0165-6147(92)90139-w

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  8 in total

1.  Regulation of the cerebellar inositol 1,4,5-trisphosphate receptor by univalent cations.

Authors:  Jean-François Coquil; Samantha Blazquez; Sabrina Soave; Jean-Pierre Mauger
Journal:  Biochem J       Date:  2004-07-15       Impact factor: 3.857

2.  Functional role for the angiotensin II receptor (AT1A) 3'-untranslated region in determining cellular responses to agonist: evidence for recognition by RNA binding proteins.

Authors:  T J Thekkumkara; W G Thomas; T J Motel; K M Baker
Journal:  Biochem J       Date:  1998-01-15       Impact factor: 3.857

3.  Pharmacologic effects of 2-methoxyestradiol on angiotensin type 1 receptor down-regulation in rat liver epithelial and aortic smooth muscle cells.

Authors:  Sivaramakrishna Koganti; Russell Snyder; Thomas Thekkumkara
Journal:  Gend Med       Date:  2012-02-25

4.  [3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties.

Authors:  David B Wainscott; Joseph H Krushinski; James E Audia; John M Schaus; John M Zgombick; Virginia L Lucaites; David L Nelson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-04-27       Impact factor: 3.000

5.  Identification of protein kinase C phosphorylation sites in the angiotensin II (AT1A) receptor.

Authors:  H Qian; L Pipolo; W G Thomas
Journal:  Biochem J       Date:  1999-11-01       Impact factor: 3.857

6.  Tannic acid down-regulates the angiotensin type 1 receptor through a MAPK-dependent mechanism.

Authors:  Rekha Yesudas; Upendra Gumaste; Russell Snyder; Thomas Thekkumkara
Journal:  Mol Endocrinol       Date:  2012-02-09

7.  Estrogen Metabolite 2-Methoxyestradiol Attenuates Blood Pressure in Hypertensive Rats by Downregulating Angiotensin Type 1 Receptor.

Authors:  Yong Zhang; Benard O Ogola; Laxmi Iyer; Vardan T Karamyan; Thomas Thekkumkara
Journal:  Front Physiol       Date:  2022-05-02       Impact factor: 4.755

8.  The inositol 1,4,5-trisphosphate receptor is localized on specialized sub-regions of the endoplasmic reticulum in rat liver.

Authors:  J P Lièvremont; A M Hill; M Hilly; J P Mauger
Journal:  Biochem J       Date:  1994-06-01       Impact factor: 3.857
  8 in total

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