[Experience in combined topiramate therapy of drug-resistant epilepsy].

Efficacy of topiramate usage in combined therapy of 35 patients (25 adults and 10 children) with therapy resistant epilepsy was analyzed. In 11.4% of the cases, medication remission for a period of up to 3 months has been achieved. Therapeutic efficacy, with reducing the number of fits by half was achieved in 40% of the cases. In children topiramate therapy was less beneficial. The authors emphasize a good tolerability of topiramate, along with a first ever described side-effect, emerging as a spot pigmentation. The results obtained reveal effectiveness of topiramate using in epileptology, in particular, in drug-resistant epilepsy.