| Literature DB >> 12937718 |
Valéria Rêgo Alves Pereira1, Virginia Maria Barros de Lorena, Mineo Nakazawa, Ana Paula Galvão da Silva, Ulisses Montarroyos, Rodrigo Correa-Oliveira, Yara de Miranda Gomes.
Abstract
Humoral and cellular immune responses were evaluated in 44 C57BL/6 mice immunized with the Trypanosoma cruzi recombinant antigens CRA and FRA. Both antigens induced cutaneous immediate-type hypersensitivity response. The levels of IgG1, IgG2a, IgG2b and IgG3 were high in CRA immunized mice. IgG3 was the predominant isotype. Although no difference in antibody levels was observed in FRA-immunized mice when compared to control mice, both antigens were able to induce lymphoproliferation in immunized mice. Significant differences were observed between incorporation of [ H]- thymidine by spleen cell stimulated in vitro with CRA or FRA and the control group. These results suggest that CRA and FRA could be involved in mechanisms of resistance to Trypanosoma cruzi infection.Entities:
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Year: 2003 PMID： 12937718 DOI： 10.1590/s0037-86822003000400001
Source DB: PubMed Journal: Rev Soc Bras Med Trop ISSN： 0037-8682 Impact factor: 1.581