OBJECTIVE: Blood donors in Brazil have been routinely screened for HTLV-I/II since 1993. A study was performed to estimate the prevalence of HTLV-I/II infection in a low risk population and to better understand determinants associated with seropositivity. METHODS: HTLV-I/II seropositive (n=135), indeterminate (n=167) and seronegative blood donors (n=116) were enrolled in an open prevalence prospective cohort study. A cross-sectional epidemiological study of positive, indeterminate and seronegative HTLV-I/II subjects was conducted to assess behavioral and environmental risk factors for seropositivity. HTLV-I/II serological status was confirmed using enzyme-linked immunosorbent assay (EIA) and Western blot (WB). RESULTS: The three groups were not homogeneous. HTLV-I/II seropositivity was associated to past blood transfusion and years of schooling, a marker of socioeconomic status, and use of non-intravenous illegal drugs. CONCLUSIONS: The study results reinforce the importance of continuous monitoring and improvement of blood donor selection process.
OBJECTIVE: Blood donors in Brazil have been routinely screened for HTLV-I/II since 1993. A study was performed to estimate the prevalence of HTLV-I/II infection in a low risk population and to better understand determinants associated with seropositivity. METHODS:HTLV-I/II seropositive (n=135), indeterminate (n=167) and seronegative blood donors (n=116) were enrolled in an open prevalence prospective cohort study. A cross-sectional epidemiological study of positive, indeterminate and seronegative HTLV-I/II subjects was conducted to assess behavioral and environmental risk factors for seropositivity. HTLV-I/II serological status was confirmed using enzyme-linked immunosorbent assay (EIA) and Western blot (WB). RESULTS: The three groups were not homogeneous. HTLV-I/II seropositivity was associated to past blood transfusion and years of schooling, a marker of socioeconomic status, and use of non-intravenous illegal drugs. CONCLUSIONS: The study results reinforce the importance of continuous monitoring and improvement of blood donor selection process.
Authors: A B F Carneiro-Proietti; M S Amaranto-Damasio; C F Leal-Horiguchi; R H C Bastos; G Seabra-Freitas; D R Borowiak; M A Ribeiro; F A Proietti; A S D Ferreira; M L Martins Journal: J Pediatric Infect Dis Soc Date: 2014-09 Impact factor: 3.164
Authors: Graça Maria de Castro Viana; Marcos Antonio Custódio Neto da Silva; Victor Lima Souza; Natália Barbosa da Silva Lopes; Maria do Desterro Soares Brandão Nascimento Journal: Rev Bras Hematol Hemoter Date: 2014-11-21
Authors: Rilma F S Santos; Gildásio C Conceição; Márcia S Martins; Angiolina Kraychete; Maria A C Penalva; Edgar M Carvalho; Antonio Alberto Lopes; Paulo Novis Rocha Journal: BMC Nephrol Date: 2017-02-15 Impact factor: 2.388
Authors: Graça Maria de Castro Viana; Maria do Desterro Soares Brandão Nascimento; Rodrigo Artur Souza de Oliveira; Alessandro Carvalho Dos Santos; Carolina de Souza Galvão; Marcos Antonio Custódio Neto da Silva Journal: Rev Bras Hematol Hemoter Date: 2014
Authors: Samantha Assis de Aguiar; Samires Avelino de Souza França; Barbara Brasil Santana; Mike Barbosa Santos; Felipe Bonfim Freitas; Glenda Ferreira; Izaura Cayres-Vallinoto; Marluísa O G Ishak; Ricardo Ishak; Antonio Carlos Rosário Vallinoto Journal: BMC Infect Dis Date: 2017-12-08 Impact factor: 3.090