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Literature DB >> 12937021

Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to beta-lactams.

Kunihiko Nishino¹, Junko Yamada, Hidetada Hirakawa, Takahiro Hirata, Akihito Yamaguchi.

Abstract

AcrAB exports some beta-lactam antibiotics in the periplasm out of cells via an outer-membrane channel, TolC. It has been reported that eight drug transporters in Escherichia coli cooperate with TolC. In this study, the roles of the drug exporters of E. coli in beta-lactam resistance were examined. We found that five of five resistance-nodulation-cell division-type drug exporters confer beta-lactam antibiotic resistance, while no other drug exporters confer any beta-lactam resistance even when they cooperate with TolC.

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Year: 2003 PMID： 12937021 PMCID： PMC182617 DOI： 10.1128/AAC.47.9.3030-3033.2003

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

32 in total

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Authors: K Nishino; A Yamaguchi
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Authors: N Kobayashi; K Nishino; A Yamaguchi
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49 in total

1. Role of histone-like protein H-NS in multidrug resistance of Escherichia coli.

Authors: Kunihiko Nishino; Akihito Yamaguchi
Journal: J Bacteriol Date: 2004-03 Impact factor: 3.490

2. AcrB-AcrA Fusion Proteins That Act as Multidrug Efflux Transporters.

Authors: Katsuhiko Hayashi; Ryosuke Nakashima; Keisuke Sakurai; Kimie Kitagawa; Seiji Yamasaki; Kunihiko Nishino; Akihito Yamaguchi
Journal: J Bacteriol Date: 2015-11-02 Impact factor: 3.490

3. Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system.

Authors: Kunihiko Nishino; Takeshi Honda; Akihito Yamaguchi
Journal: J Bacteriol Date: 2005-03 Impact factor: 3.490

4. Correlation between ceftriaxone resistance of Salmonella enterica serovar Typhimurium and expression of outer membrane proteins OmpW and Ail/OmpX-like protein, which are regulated by BaeR of a two-component system.

Authors: Wensi S Hu; Pei-Chuan Li; Chao-Yin Cheng
Journal: Antimicrob Agents Chemother Date: 2005-09 Impact factor: 5.191

5. Growth phase-dependent expression of drug exporters in Escherichia coli and its contribution to drug tolerance.

Authors: Asuka Kobayashi; Hidetada Hirakawa; Takahiro Hirata; Kunihiko Nishino; Akihito Yamaguchi
Journal: J Bacteriol Date: 2006-08 Impact factor: 3.490

6. MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.

Authors: Hiroyasu Yamanaka; Hidetomo Kobayashi; Eizo Takahashi; Keinosuke Okamoto
Journal: J Bacteriol Date: 2008-09-19 Impact factor: 3.490

7. Effect of NlpE overproduction on multidrug resistance in Escherichia coli.

Authors: Kunihiko Nishino; Seiji Yamasaki; Mitsuko Hayashi-Nishino; Akihito Yamaguchi
Journal: Antimicrob Agents Chemother Date: 2010-03-08 Impact factor: 5.191

8. Global transcriptional analysis of stress-response strategies in Acidithiobacillus ferrooxidans ATCC 23270 exposed to organic extractant--Lix984n.

Authors: Zhijun Zhou; Yun Fang; Qihou Li; Huaqun Yin; Wenqing Qin; Yili Liang; Qian Li; Nuo Li; Xinxing Liu; Guanzhou Qiu; Xueduan Liu
Journal: World J Microbiol Biotechnol Date: 2011-10-01 Impact factor: 3.312

9. β-Lactam selectivity of multidrug transporters AcrB and AcrD resides in the proximal binding pocket.

Authors: Naoki Kobayashi; Norihisa Tamura; Hendrik W van Veen; Akihito Yamaguchi; Satoshi Murakami
Journal: J Biol Chem Date: 2014-02-20 Impact factor: 5.157

10. The TolC protein of Legionella pneumophila plays a major role in multi-drug resistance and the early steps of host invasion.

Authors: Mourad Ferhat; Danièle Atlan; Anne Vianney; Jean-Claude Lazzaroni; Patricia Doublet; Christophe Gilbert
Journal: PLoS One Date: 2009-11-04 Impact factor: 3.240