Literature DB >> 12935312

Structure-activity relationship of 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone).

Kazutoshi Watanabe1, Yasuhiro Morinaka, Katsuhiko Iseki, Toshiaki Watanabe, Satoshi Yuki, Hiroyoshi Nishi.   

Abstract

This paper describes the discovery of a novel free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone, 1), as a potent antioxidant agent against lipid peroxidation. The structure-activity relationship of edaravone indicated that lipophilic substituents were essential to show its lipid peroxidation-inhibitory activity. In vivo studies revealed that edaravone showed brain-protective activity in a transient ischemia model.

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Year:  2003        PMID： 12935312     DOI： 10.1179/135100003225001520

Source DB:  PubMed          Journal:  Redox Rep        ISSN： 1351-0002            Impact factor:   4.412


  8 in total

1.  The edaravone and 3-n-butylphthalide ring-opening derivative 10b effectively attenuates cerebral ischemia injury in rats.

Authors:  Kai Hua; Xiao Sheng; Ting-ting Li; Lin-na Wang; Yi-hua Zhang; Zhang-jian Huang; Hui Ji
Journal:  Acta Pharmacol Sin       Date:  2015-06-15       Impact factor: 6.150

2.  Antioxidant treatment with edaravone or taurine ameliorates diabetes-induced testicular dysfunction in the rat.

Authors:  Panagiota Tsounapi; Motoaki Saito; Fotios Dimitriadis; Sotirios Koukos; Shogo Shimizu; Keisuke Satoh; Atsushi Takenaka; Nikolaos Sofikitis
Journal:  Mol Cell Biochem       Date:  2012-07-05       Impact factor: 3.396

3.  Effects of edaravone on amyloid-β precursor protein processing in SY5Y-APP695 cells.

Authors:  Yue-E Shen; Yan Wang; Gui-Chun Yu; Chao Liu; Zhen-Yu Zhang; Li-Ming Zhang
Journal:  Neurotox Res       Date:  2013-01-17       Impact factor: 3.911

4.  Impact of antioxidants on seminal vesicles function and fertilizing potential in diabetic rats.

Authors:  Panagiota Tsounapi; Masashi Honda; Fotios Dimitriadis; Bunya Kawamoto; Katsuya Hikita; Kuniyasu Muraoka; Motoaki Saito; Nikolaos Sofikitis; Atsushi Takenaka
Journal:  Asian J Androl       Date:  2017 Nov-Dec       Impact factor: 3.285

Review 5.  Comprehensive Research on Past and Future Therapeutic Strategies Devoted to Treatment of Amyotrophic Lateral Sclerosis.

Authors:  Belgin Sever; Halilibrahim Ciftci; Hasan DeMirci; Hilal Sever; Firdevs Ocak; Burak Yulug; Hiroshi Tateishi; Takahisa Tateishi; Masami Otsuka; Mikako Fujita; Ayşe Nazlı Başak
Journal:  Int J Mol Sci       Date:  2022-02-22       Impact factor: 5.923

Review 6.  How is edaravone effective against acute ischemic stroke and amyotrophic lateral sclerosis?

Authors:  Kazutoshi Watanabe; Masahiko Tanaka; Satoshi Yuki; Manabu Hirai; Yorihiro Yamamoto
Journal:  J Clin Biochem Nutr       Date:  2017-11-11       Impact factor: 3.114

7.  Design, synthesis and biological evaluation of edaravone derivatives bearing the N-benzyl pyridinium moiety as multifunctional anti-Alzheimer's agents.

Authors:  Luke S Zondagh; Sarel F Malan; Jacques Joubert
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051

8.  SMTP-44D improves diabetic neuropathy symptoms in mice through its antioxidant and anti-inflammatory activities.

Authors:  Ryosuke Shinouchi; Keita Shibata; Terumasa Hashimoto; Shiori Jono; Keiji Hasumi; Koji Nobe
Journal:  Pharmacol Res Perspect       Date:  2020-12
  8 in total

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