Literature DB >> 12934680

Impact of dietary n-3 FA deficiency on rat bone tissue FA composition.

Yong Li1, Rebecca S Greiner, Norman Salem, Bruce A Watkins.   

Abstract

The effect of dietary n-3 FA deficiency on bone tissue FA composition was evaluated in growing rats. Two mixtures combining hydrogenated coconut oil with safflower oil served as the n-3-deficient dietary treatments and provided two levels of linoleic acid (LA). The n-3 treatments were formulated with added alpha-linolenic acid (LNA) from flaxseed oil (diet LNA) or LNA plus DHA, and both were balanced for LA. This study showed that bone is sensitive to changes in dietary n-3 FA and that DHA is more effective than LNA in maintaining DHA levels in these tissues.

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Year:  2003        PMID: 12934680     DOI: 10.1007/s11745-003-1115-8

Source DB:  PubMed          Journal:  Lipids        ISSN: 0024-4201            Impact factor:   1.880


  5 in total

Review 1.  Bioactive fatty acids: role in bone biology and bone cell function.

Authors:  B A Watkins; H E Lippman; L Le Bouteiller; Y Li; M F Seifert
Journal:  Prog Lipid Res       Date:  2001 Jan-Mar       Impact factor: 16.195

2.  Olfactory discrimination deficits in n-3 fatty acid-deficient rats.

Authors:  R S Greiner; T Moriguchi; B M Slotnick; A Hutton; N Salem
Journal:  Physiol Behav       Date:  2001-02

3.  Differential effects of n-3 fatty acid deficiency on phospholipid molecular species composition in the rat hippocampus.

Authors:  Mahadev Murthy; Jillonne Hamilton; Rebecca S Greiner; Toru Moriguchi; Norman Salem; Hee-Yong Kim
Journal:  J Lipid Res       Date:  2002-04       Impact factor: 5.922

4.  Dietary ratio of (n-6)/(n-3) polyunsaturated fatty acids alters the fatty acid composition of bone compartments and biomarkers of bone formation in rats.

Authors:  B A Watkins; Y Li; K G Allen; W E Hoffmann; M F Seifert
Journal:  J Nutr       Date:  2000-09       Impact factor: 4.798

5.  Dietary conjugated linoleic acids alter serum IGF-I and IGF binding protein concentrations and reduce bone formation in rats fed (n-6) or (n-3) fatty acids.

Authors:  Y Li; M F Seifert; D M Ney; M Grahn; A L Grant; K G Allen; B A Watkins
Journal:  J Bone Miner Res       Date:  1999-07       Impact factor: 6.741

  5 in total
  6 in total

1.  Docosahexaenoyl ethanolamide improves glucose uptake and alters endocannabinoid system gene expression in proliferating and differentiating C2C12 myoblasts.

Authors:  Jeffrey Kim; Morgan E Carlson; Bruce A Watkins
Journal:  Front Physiol       Date:  2014-03-21       Impact factor: 4.566

2.  Low Levels of Omega-3 Long-Chain Polyunsaturated Fatty Acids Are Associated with Bone Metastasis Formation in Premenopausal Women with Breast Cancer: A Retrospective Study.

Authors:  Caroline Goupille; Philippe G Frank; Flavie Arbion; Marie-Lise Jourdan; Cyrille Guimaraes; Michelle Pinault; Gilles Body; Stephan Chevalier; Philippe Bougnoux; Lobna Ouldamer
Journal:  Nutrients       Date:  2020-12-15       Impact factor: 5.717

3.  Dietary DHA reduces downstream endocannabinoid and inflammatory gene expression and epididymal fat mass while improving aspects of glucose use in muscle in C57BL/6J mice.

Authors:  J Kim; M E Carlson; G A Kuchel; J W Newman; B A Watkins
Journal:  Int J Obes (Lond)       Date:  2015-07-29       Impact factor: 5.095

Review 4.  Investigating the role of polyunsaturated fatty acids in bone development using animal models.

Authors:  Beatrice Y Y Lau; Daniel J A Cohen; Wendy E Ward; David W L Ma
Journal:  Molecules       Date:  2013-11-15       Impact factor: 4.411

5.  Effect of hydroalcoholic extract of flaxseed on bone mineral density in Wistar rats using digital radiography.

Authors:  Farideh Nozari Moshtaghin; Ali Akbar Moghadamnia; Sohrab Kazemi; Nazanin Arbabzadegan; Ehsan Moudi; Sina Haghanifar
Journal:  Caspian J Intern Med       Date:  2020

Review 6.  Dual Effects of Lipid Metabolism on Osteoblast Function.

Authors:  Nathalie S Alekos; Megan C Moorer; Ryan C Riddle
Journal:  Front Endocrinol (Lausanne)       Date:  2020-09-23       Impact factor: 5.555

  6 in total

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