Literature DB >> 12933950

Anti-Ma2 antibody related paraneoplastic limbic/brain stem encephalitis associated with breast cancer expressing Ma1, Ma2, and Ma3 mRNAs.

K Sahashi1, K Sakai, K Mano, G Hirose.   

Abstract

A 69 year old woman presented with cognitive impairment and supranuclear gaze palsy caused by paraneoplastic limbic/brain stem encephalitis associated with atypical medullary breast carcinoma. The cerebrospinal fluid from the patient harboured an anti-neuronal cell antibody against Ma2 antigen, but not against Ma1 or Ma3 antigen. Despite the antibody being restricted to the Ma2 antigen, the patient's cancer tissue expressed Ma1, Ma2, and Ma3 mRNAs. These results, and the expression of Ma2 mRNA in an atypical medullar breast carcinoma in another patient without paraneoplastic encephalitis, indicate that the induction of anti-Ma2 antibody depends on host immunoreponsiveness and not on the presence of the antigen itself in the cancer.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12933950      PMCID： PMC1738632          DOI： 10.1136/jnnp.74.9.1332

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  14 in total

1.  Paraneoplastic brainstem encephalitis in a patient with malignant fibrous histiocytoma and atypical anti-neuronal antibodies.

Authors:  Manuel Corato; Kalliope Marinou-Aktipi; Rosanna Nano; Bruno Giometto; Cristina Cereda; Guido Natoli; Angelica Facoetti; Mauro Ceroni
Journal:  J Neurol       Date:  2004-11       Impact factor: 4.849

2.  Anti-Ma2 antibodies in B-cell primary CNS lymphoma.

Authors:  Markus Kraemer; Peter Berlit
Journal:  J Neurol       Date:  2007-04-10       Impact factor: 4.849

Review 3.  Paraneoplastic syndromes of the CNS.

Authors:  Josep Dalmau; Myrna R Rosenfeld
Journal:  Lancet Neurol       Date:  2008-04       Impact factor: 44.182

4.  Anti-Ta-associated paraneoplastic encephalitis with occult testicular intratubular germ-cell neoplasia.

Authors:  Harald Prüss; Raymond Voltz; Bernd Flath; Birgit Rudolph; Randolf Klingebiel; Rolf Zschenderlein; Konstantin Prass
Journal:  J Neurol Neurosurg Psychiatry       Date:  2007-06       Impact factor: 10.154

5.  Anti-Ma2 associated paraneoplastic neurological syndrome presenting as encephalitis and progressive muscular atrophy.

Authors:  M Waragai; A Chiba; A Uchibori; T Fukushima; M Anno; K Tanaka
Journal:  J Neurol Neurosurg Psychiatry       Date:  2006-01       Impact factor: 10.154

Review 6.  Chorea and related movement disorders of paraneoplastic origin: the PNS EuroNetwork experience.

Authors:  Maria Claudia Vigliani; Jerome Honnorat; Jean-Christophe Antoine; Roberta Vitaliani; Bruno Giometto; Dimitri Psimaras; Federica Franchino; Carlotta Rossi; Francesc Graus
Journal:  J Neurol       Date:  2011-05-11       Impact factor: 4.849

7.  Screening for tumours in paraneoplastic syndromes: report of an EFNS task force.

Authors:  M J Titulaer; R Soffietti; J Dalmau; N E Gilhus; B Giometto; F Graus; W Grisold; J Honnorat; P A E Sillevis Smitt; R Tanasescu; C A Vedeler; R Voltz; J J G M Verschuuren
Journal:  Eur J Neurol       Date:  2010-09-29       Impact factor: 6.089

Review 8.  Advances in Autoimmune Epilepsy Associated with Antibodies, Their Potential Pathogenic Molecular Mechanisms, and Current Recommended Immunotherapies.

Authors:  Zhiwei Fang; Yunqi Yang; Xuan Chen; Weiwang Zhang; Yangmei Xie; Yinghui Chen; Zhenguo Liu; Weien Yuan
Journal:  Front Immunol       Date:  2017-04-25       Impact factor: 7.561

Review 9.  Review of paraneoplastic syndromes in children.

Authors:  Grace My Ma; Jeanne S Chow; George A Taylor
Journal:  Pediatr Radiol       Date:  2019-03-16

10.  Distinct functional domains of PNMA5 mediate protein-protein interaction, nuclear localization, and apoptosis signaling in human cancer cells.

Authors:  Yong Hoi Lee; Siew Wai Pang; Chit Laa Poh; Kuan Onn Tan
Journal:  J Cancer Res Clin Oncol       Date:  2016-07-16       Impact factor: 4.553
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.