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Literature DB >> 12933893

Genetic variation influences the B-cell response to immunization with a pneumococcal polysaccharide conjugate vaccine.

T L McCool¹, J R Schreiber, N S Greenspan.

Abstract

CBA/J mice immunized with pneumococcal 23F-CRM(197) vaccine produce significantly lower titers of 23F-specific antibodies and fewer 23F-specific antibody-secreting cells (ASC) than did BALB/c or (CBA/J x BALB/c)F(1) (CCBAF(1)) mice. The reduced 23F-specific titers of CBA/J versus BALB/c or CCBAF(1) mice are presumably related to lower frequencies of 23F-specific ASC influenced by genetic variation.

Entities: Disease Species

Mesh：

Substances：

Year: 2003 PMID： 12933893 PMCID： PMC187339 DOI： 10.1128/IAI.71.9.5402-5406.2003

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

9 in total

1. B- and T-cell immune responses to pneumococcal conjugate vaccines: divergence between carrier- and polysaccharide-specific immunogenicity.

Authors: T L McCool; C V Harding; N S Greenspan; J R Schreiber
Journal: Infect Immun Date: 1999-09 Impact factor: 3.441

Review 2. Genetic control of the immunologic response to pneumococcal capsular polysaccharides.

Authors: D M Musher; D A Watson; R E Baughn
Journal: Vaccine Date: 2000-11-08 Impact factor: 3.641

3. Recurrent variable region gene usage and somatic mutation in the human antibody response to the capsular polysaccharide of Streptococcus pneumoniae type 23F.

Authors: Jianhui Zhou; Kathleen R Lottenbach; Stephen J Barenkamp; Alexander H Lucas; Donald C Reason
Journal: Infect Immun Date: 2002-08 Impact factor: 3.441

4. Significant variation in serotype-specific immunogenicity of the seven-valent Streptococcus pneumoniae capsular polysaccharide-CRM197 conjugate vaccine occurs despite vigorous T cell help induced by the carrier protein.

Authors: Kulwant K Kamboj; H Lester Kirchner; Rhonda Kimmel; Neil S Greenspan; John R Schreiber
Journal: J Infect Dis Date: 2003-04-30 Impact factor: 5.226

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Authors: P J Baker; D W Bailey; M B Fauntleroy; P W Stashak; G Caldes; B Prescott
Journal: Immunogenetics Date: 1985 Impact factor: 2.846

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Authors: G P van den Dobbelsteen; H Kroes; E P van Rees
Journal: Scand J Immunol Date: 1995-03 Impact factor: 3.487

7. Safety and immunogenicity of heptavalent pneumococcal CRM197 conjugate vaccine in infants and toddlers.

Authors: H R Shinefield; S Black; P Ray; I Chang; N Lewis; B Fireman; J Hackell; P R Paradiso; G Siber; R Kohberger; D V Madore; F J Malinowski; A Kimura; C Le; I Landaw; J Aguilar; J Hansen
Journal: Pediatr Infect Dis J Date: 1999-09 Impact factor: 2.129

8. Genetic regulation of the capacity to make immunoglobulin G to pneumococcal capsular polysaccharides.

Authors: D M Musher; J E Groover; D A Watson; J P Pandey; M C Rodriguez-Barradas; R E Baughn; M S Pollack; E A Graviss; M de Andrade; C I Amos
Journal: J Investig Med Date: 1997-02 Impact factor: 2.895

9. Safety and immunogenicity of heptavalent pneumococcal vaccine conjugated to CRM197 in United States infants.

Authors: M B Rennels; K M Edwards; H L Keyserling; K S Reisinger; D A Hogerman; D V Madore; I Chang; P R Paradiso; F J Malinoski; A Kimura
Journal: Pediatrics Date: 1998-04 Impact factor: 7.124