Literature DB >> 12933886

Accumulation of Clostridium perfringens epsilon-toxin in the mouse kidney and its possible biological significance.

Eiji Tamai1, Tetsuya Ishida, Shigeru Miyata, Osamu Matsushita, Hirofumi Suda, Shoji Kobayashi, Hiroshi Sonobe, Akinobu Okabe.   

Abstract

In this paper we show that Clostridium perfringens epsilon-toxin accumulates predominantly in the mouse kidney, where it is distributed mainly in glomeruli, capillaries, and collecting ducts. Although some pycnotic and exfoliated epithelial cells were observed in distal tubuli and collecting ducts, there were no findings indicative of severe renal injury. Bilateral nephrectomy increased the mouse lethality of the toxin, suggesting that the kidney contributes to the host defense against the lethal toxicity of epsilon-toxin.

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Year:  2003        PMID： 12933886      PMCID： PMC187324          DOI： 10.1128/IAI.71.9.5371-5375.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  22 in total

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Authors:  M Nagahama; S Ochi; J Sakurai
Journal:  J Nat Toxins       Date:  1998-10

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Authors:  J Parkkinen; R Virkola; T K Korhonen
Journal:  Infect Immun       Date:  1988-10       Impact factor: 3.441

Review 3.  Clostridial enteric diseases of domestic animals.

Authors:  J G Songer
Journal:  Clin Microbiol Rev       Date:  1996-04       Impact factor: 26.132

4.  Lambda-toxin of Clostridium perfringens activates the precursor of epsilon-toxin by releasing its N- and C-terminal peptides.

Authors:  J Minami; S Katayama; O Matsushita; C Matsushita; A Okabe
Journal:  Microbiol Immunol       Date:  1997       Impact factor: 1.955

5.  Neurotoxicity of Clostridium perfringens epsilon-toxin for the rat hippocampus via the glutamatergic system.

Authors:  O Miyamoto; J Minami; T Toyoshima; T Nakamura; T Masada; S Nagao; T Negi; T Itano; A Okabe
Journal:  Infect Immun       Date:  1998-06       Impact factor: 3.441

6.  Clostridium perfringens epsilon-toxin acts on MDCK cells by forming a large membrane complex.

Authors:  L Petit; M Gibert; D Gillet; C Laurent-Winter; P Boquet; M R Popoff
Journal:  J Bacteriol       Date:  1997-10       Impact factor: 3.490

7.  Phylogenetic analysis of phospholipase C genes from Clostridium perfringens types A to E and Clostridium novyi.

Authors:  K Tsutsui; J Minami; O Matsushita; S Katayama; Y Taniguchi; S Nakamura; M Nishioka; A Okabe
Journal:  J Bacteriol       Date:  1995-12       Impact factor: 3.490

8.  Comparison of the alpha-toxin genes of Clostridium perfringens type A and C strains: evidence for extragenic regulation of transcription.

Authors:  S Katayama; O Matsushita; J Minami; S Mizobuchi; A Okabe
Journal:  Infect Immun       Date:  1993-02       Impact factor: 3.441

9.  Quantitation of Tamm-Horsfall protein binding to uropathogenic Escherichia coli and lectins.

Authors:  H H Reinhart; N Obedeanu; J D Sobel
Journal:  J Infect Dis       Date:  1990-12       Impact factor: 5.226

10.  Molecular composition of Clostridium botulinum type A progenitor toxins.

Authors:  K Inoue; Y Fujinaga; T Watanabe; T Ohyama; K Takeshi; K Moriishi; H Nakajima; K Inoue; K Oguma
Journal:  Infect Immun       Date:  1996-05       Impact factor: 3.441
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  23 in total

1.  Treatment for chemotherapy-induced alopecia in mice using parathyroid hormone agonists and antagonists linked to a collagen binding domain.

Authors:  Ranjitha Katikaneni; Tulasi Ponnapakkam; Hirofumi Suda; Shigeru Miyata; Joshua Sakon; Osamu Matsushita; Robert C Gensure
Journal:  Int J Cancer       Date:  2012-01-24       Impact factor: 7.396

2.  The Cytotoxicity of Epsilon Toxin from Clostridium perfringens on Lymphocytes Is Mediated by MAL Protein Expression.

Authors:  Marta Blanch; Jonatan Dorca-Arévalo; Anna Not; Mercè Cases; Inmaculada Gómez de Aranda; Antonio Martínez-Yélamos; Sergio Martínez-Yélamos; Carles Solsona; Juan Blasi
Journal:  Mol Cell Biol       Date:  2018-09-14       Impact factor: 4.272

3.  A single injection of the anabolic bone agent, parathyroid hormone-collagen binding domain (PTH-CBD), results in sustained increases in bone mineral density for up to 12 months in normal female mice.

Authors:  Tulasi Ponnapakkam; Ranjitha Katikaneni; Hirofumi Suda; Shigeru Miyata; Osamu Matsushita; Joshua Sakon; Robert C Gensure
Journal:  Calcif Tissue Int       Date:  2012-07-18       Impact factor: 4.333

4.  Identification of amino acids important for binding of Clostridium perfringens epsilon toxin to host cells and to HAVCR1.

Authors:  Susan E Ivie; Mark S McClain
Journal:  Biochemistry       Date:  2012-09-12       Impact factor: 3.162

5.  Identification of Small Molecule Inhibitors of Clostridium perfringens ε-Toxin Cytotoxicity Using a Cell-Based High-Throughput Screen.

Authors:  Michelle Lewis; Charles David Weaver; Mark S McClain
Journal:  Toxins (Basel)       Date:  2010-07-01       Impact factor: 5.075

Review 6.  Toxin plasmids of Clostridium perfringens.

Authors:  Jihong Li; Vicki Adams; Trudi L Bannam; Kazuaki Miyamoto; Jorge P Garcia; Francisco A Uzal; Julian I Rood; Bruce A McClane
Journal:  Microbiol Mol Biol Rev       Date:  2013-06       Impact factor: 11.056

Review 7.  Pathogenesis and diagnostic features of brain and ophthalmic damage produced by Clostridium perfringens type D epsilon toxin.

Authors:  John W Finnie; Mauricio A Navarro; Francisco A Uzal
Journal:  J Vet Diagn Invest       Date:  2020-01-20       Impact factor: 1.279

8.  Evidence for a prepore stage in the action of Clostridium perfringens epsilon toxin.

Authors:  Susan L Robertson; Jihong Li; Francisco A Uzal; Bruce A McClane
Journal:  PLoS One       Date:  2011-07-11       Impact factor: 3.240

9.  New Mutants of Epsilon Toxin from Clostridium perfringens with an Altered Receptor-Binding Site and Cell-Type Specificity.

Authors:  Jonatan Dorca-Arévalo; Inmaculada Gómez de Aranda; Juan Blasi
Journal:  Toxins (Basel)       Date:  2022-04-16       Impact factor: 5.075

10.  Clostridium perfringens epsilon toxin increases the small intestinal permeability in mice and rats.

Authors:  Jorge Goldstein; Winston E Morris; César Fabián Loidl; Carla Tironi-Farinati; Carla Tironi-Farinatti; Bruce A McClane; Francisco A Uzal; Mariano E Fernandez Miyakawa
Journal:  PLoS One       Date:  2009-09-18       Impact factor: 3.240
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