OBJECTIVE: Circulating levels of C-reactive protein (CRP) predict cardiovascular events. In contrast, an association between CRP and direct measures of atherosclerosis has not been established clearly. In the largest study to date, we examined the association of plasma CRP with coronary artery calcification (CAC) in 914 asymptomatic subjects in the Study of Inherited Risk of Coronary Atherosclerosis (SIRCA). METHODS AND RESULTS: In age-adjusted, cross-sectional analysis, there was a weak association between plasma CRP levels and CAC in women (odds ratio [OR] for ordinal regression, 1.1 [1.04 to 1.17] per 1.0 mg/L increase in CRP; P=0.005) but not in men. The association between CRP and CAC in women remained significant after adjusting for traditional risk factors (OR, 1.08 [1.00 to 1.14]; P=0.048) but was lost after further adjustment for body mass index (BMI) (OR, 1.02 [0.94 to 1.08]; P=0.7). CONCLUSIONS: In SIRCA, CRP was not associated with CAC in men, and a weak association in women was lost after adjustment for BMI. The relation between CRP and clinical events might not be related to atherosclerotic burden. Measures of inflammation, such as CRP, and indices of atherosclerosis, such as CAC, are likely to provide distinct information regarding cardiovascular risk.
OBJECTIVE: Circulating levels of C-reactive protein (CRP) predict cardiovascular events. In contrast, an association between CRP and direct measures of atherosclerosis has not been established clearly. In the largest study to date, we examined the association of plasma CRP with coronary artery calcification (CAC) in 914 asymptomatic subjects in the Study of Inherited Risk of Coronary Atherosclerosis (SIRCA). METHODS AND RESULTS: In age-adjusted, cross-sectional analysis, there was a weak association between plasma CRP levels and CAC in women (odds ratio [OR] for ordinal regression, 1.1 [1.04 to 1.17] per 1.0 mg/L increase in CRP; P=0.005) but not in men. The association between CRP and CAC in women remained significant after adjusting for traditional risk factors (OR, 1.08 [1.00 to 1.14]; P=0.048) but was lost after further adjustment for body mass index (BMI) (OR, 1.02 [0.94 to 1.08]; P=0.7). CONCLUSIONS: In SIRCA, CRP was not associated with CAC in men, and a weak association in women was lost after adjustment for BMI. The relation between CRP and clinical events might not be related to atherosclerotic burden. Measures of inflammation, such as CRP, and indices of atherosclerosis, such as CAC, are likely to provide distinct information regarding cardiovascular risk.
Authors: Anurag Mehta; Jaideep Patel; Mahmoud Al Rifai; Colby R Ayers; Ian J Neeland; Alka M Kanaya; Namratha Kandula; Michael J Blaha; Khurram Nasir; Roger S Blumenthal; Parag H Joshi Journal: Atherosclerosis Date: 2018-01-31 Impact factor: 5.162
Authors: Jane F Ferguson; Christine C Hinkle; Nehal N Mehta; Roshanak Bagheri; Stephanie L Derohannessian; Rhia Shah; Megan I Mucksavage; Jonathan P Bradfield; Hakon Hakonarson; Xuexia Wang; Stephen R Master; Daniel J Rader; Mingyao Li; Muredach P Reilly Journal: J Am Coll Cardiol Date: 2012-02-21 Impact factor: 24.094
Authors: Fabian Bamberg; Quynh A Truong; Wolfgang Koenig; Christopher L Schlett; Khurram Nasir; Javed Butler; Emily Kurtz; Konstantin Nikolaou; Udo Hoffmann; James L Januzzi Journal: Int J Cardiovasc Imaging Date: 2011-01-09 Impact factor: 2.357
Authors: Michael D Crosier; Sarah L Booth; Inga Peter; Bess Dawson-Hughes; Paul A Price; Christopher J O'Donnell; Udo Hoffmann; Matthew K Williamson; Jose M Ordovas Journal: J Nutr Sci Vitaminol (Tokyo) Date: 2009-02 Impact factor: 2.000
Authors: Nancy Swords Jenny; Elizabeth R Brown; Robert Detrano; Aaron R Folsom; Mohammed F Saad; Steven Shea; Moyses Szklo; David M Herrington; David R Jacobs Journal: Atherosclerosis Date: 2009-08-28 Impact factor: 5.162