OBJECTIVE: Low-grade inflammation may raise serum C-reactive protein (CRP) concentrations. We studied whether serum CRP is altered in preterm premature rupture of membranes (PPROM), which is frequently associated with an asymptomatic intrauterine infection. STUDY DESIGN: CRP was quantitated with highly sensitive immunofluorometric (IFMA) and immunoenzymometric (IEMA) assays in 32 women with PPROM at 30.7+/-0.4 gestational weeks (mean+/-standard error of the mean) and in 27 gestational age-matched healthy women. The results were compared to those obtained by the conventional immunoturbidimetric method. RESULTS: Twenty-three PPROM patients had a normal CRP value (</=12mg/l) by immunoturbidimetry. Their highly sensitive CRP value was not different from that of controls. During the observation period of 11+/-3 days after PPROM, an increase in the highly sensitive CRP was observed in patients whose immunoturbidimetric CRP remained normal (n=10). CONCLUSION: The increase in the highly sensitive CRP in PPROM patients with constantly normal immunoturbidimetric CRP may reflect the presence of a subclinical inflammation.
OBJECTIVE: Low-grade inflammation may raise serum C-reactive protein (CRP) concentrations. We studied whether serum CRP is altered in preterm premature rupture of membranes (PPROM), which is frequently associated with an asymptomatic intrauterine infection. STUDY DESIGN:CRP was quantitated with highly sensitive immunofluorometric (IFMA) and immunoenzymometric (IEMA) assays in 32 women with PPROM at 30.7+/-0.4 gestational weeks (mean+/-standard error of the mean) and in 27 gestational age-matched healthy women. The results were compared to those obtained by the conventional immunoturbidimetric method. RESULTS: Twenty-three PPROM patients had a normal CRP value (</=12mg/l) by immunoturbidimetry. Their highly sensitive CRP value was not different from that of controls. During the observation period of 11+/-3 days after PPROM, an increase in the highly sensitive CRP was observed in patients whose immunoturbidimetric CRP remained normal (n=10). CONCLUSION: The increase in the highly sensitive CRP in PPROM patients with constantly normal immunoturbidimetric CRP may reflect the presence of a subclinical inflammation.
Authors: Waranuch Pitiphat; Matthew W Gillman; Kaumudi J Joshipura; Paige L Williams; Chester W Douglass; Janet W Rich-Edwards Journal: Am J Epidemiol Date: 2005-10-19 Impact factor: 4.897
Authors: Rebecca A Howman; Adrian K Charles; Angela Jacques; Dorota A Doherty; Karen Simmer; Tobias Strunk; Peter C Richmond; Catherine H Cole; David P Burgner Journal: PLoS One Date: 2012-12-13 Impact factor: 3.240