Low doses of interleukin-1beta improve the leverpress avoidance performance of Sprague-Dawley rats.

Recent research has indicated that the pro-inflammatory cytokines, particularly interleukin-1beta (IL-1beta), can affect learning and memory. We injected male Sprague-Dawley rats with IL-1beta (1.0, 3.0, or 6.0 microg/kg, i.p.) or saline vehicle, 24h before a single 4-h session of leverpress escape/avoidance conditioning. No effect of IL-1beta at any dose was observed in the number of escape responses across the 4-h session. However, subjects treated with the two lower doses (1.0 and 3.0 microg/kg) of IL-1beta performed more avoidance responses during the final hour of the 4-h session than the other two groups. Subjects treated with the highest dose of IL-1beta (6.0 microg/kg) did not differ from controls. Results are discussed in terms of the possible mechanisms behind the IL-1beta-induced enhancement of learning, as well as the observed dose-response relationship.