Literature DB >> 12932143

Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.

Xing-Cong Li1, Melissa R Jacob, Hala N ElSohly, Dale G Nagle, Troy J Smillie, Larry A Walker, Alice M Clark.   

Abstract

Antifungal bioassay-guided isolation of the ethanol extract of the roots of Pentagonia gigantifolia yielded 6-octadecynoic acid (1) and the new 6-nonadecynoic acid (2). Compounds 1 and 2 inhibited the growth of fluconazole-susceptible and -resistant Candida albicans strains. Their antifungal potencies were comparable to those of amphotericin B and fluconazole. Of particular significance is the low cytotoxicity and specific activity of 1 and 2 against C. albicans.

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Year:  2003        PMID： 12932143     DOI： 10.1021/np030196r

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  16 in total

1.  Cycloartane glycosides from Sutherlandia frutescens.

Authors:  Xiang Fu; Xing-Cong Li; Troy J Smillie; Paulo Carvalho; Wilfred Mabusela; James Syce; Quinton Johnson; William Folk; Mitchell A Avery; Ikhlas A Khan
Journal:  J Nat Prod       Date:  2008-09-23       Impact factor: 4.050

Review 2.  Antimicrobial Lipids from Plants and Marine Organisms: An Overview of the Current State-of-the-Art and Future Prospects.

Authors:  Eliana Alves; Marina Dias; Diana Lopes; Adelaide Almeida; Maria do Rosário Domingues; Felisa Rey
Journal:  Antibiotics (Basel)       Date:  2020-07-24

3.  2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani.

Authors:  Néstor M Carballeira; Michelle Cartagena; David Sanabria; Deniz Tasdemir; Christopher F Prada; Rosa M Reguera; Rafael Balaña-Fouce
Journal:  Bioorg Med Chem Lett       Date:  2012-08-10       Impact factor: 2.823

4.  2,6-hexadecadiynoic acid and 2,6-nonadecadiynoic acid: novel synthesized acetylenic fatty acids as potent antifungal agents.

Authors:  Néstor M Carballeira; David Sanabria; Clarisa Cruz; Keykavous Parang; Baojie Wan; Scott Franzblau
Journal:  Lipids       Date:  2006-05       Impact factor: 1.880

5.  Capisterones A and B, which enhance fluconazole activity in Saccharomyces cerevisiae, from the marine green alga Penicillus capitatus.

Authors:  Xing-Cong Li; Melissa R Jacob; Yuanqing Ding; Ameeta K Agarwal; Troy J Smillie; Shabana I Khan; Dale G Nagle; Daneel Ferreira; Alice M Clark
Journal:  J Nat Prod       Date:  2006-04       Impact factor: 4.050

6.  A potent plant-derived antifungal acetylenic acid mediates its activity by interfering with fatty acid homeostasis.

Authors:  Tao Xu; Siddharth K Tripathi; Qin Feng; Michael C Lorenz; Marsha A Wright; Melissa R Jacob; Melanie M Mask; Scott R Baerson; Xing-Cong Li; Alice M Clark; Ameeta K Agarwal
Journal:  Antimicrob Agents Chemother       Date:  2012-03-19       Impact factor: 5.191

7.  Potent in vitro antifungal activities of naturally occurring acetylenic acids.

Authors:  Xing-Cong Li; Melissa R Jacob; Shabana I Khan; M Khalid Ashfaq; K Suresh Babu; Ameeta K Agarwal; Hala N Elsohly; Susan P Manly; Alice M Clark
Journal:  Antimicrob Agents Chemother       Date:  2008-05-05       Impact factor: 5.191

Review 8.  Biosynthesis and function of polyacetylenes and allied natural products.

Authors:  Robert E Minto; Brenda J Blacklock
Journal:  Prog Lipid Res       Date:  2008-03-13       Impact factor: 16.195

9.  Antibacterial activity of 2-alkynoic fatty acids against multidrug-resistant bacteria.

Authors:  David J Sanabria-Ríos; Yaritza Rivera-Torres; Gamalier Maldonado-Domínguez; Idializ Domínguez; Camille Ríos; Damarith Díaz; José W Rodríguez; Joanne S Altieri-Rivera; Eddy Ríos-Olivares; Gabriel Cintrón; Nashbly Montano; Néstor M Carballeira
Journal:  Chem Phys Lipids       Date:  2013-12-21       Impact factor: 3.329

10.  A multifunctional desaturase involved in the biosynthesis of the processionary moth sex pheromone.

Authors:  Montserrat Serra; Benjamin Piña; José Luis Abad; Francisco Camps; Gemma Fabriàs
Journal:  Proc Natl Acad Sci U S A       Date:  2007-10-05       Impact factor: 11.205
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