Literature DB >> 12932141

Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.

Kenji Matsumoto1, Yukihiro Akao, Emi Kobayashi, Kenji Ohguchi, Tetsuro Ito, Toshiyuki Tanaka, Munekazu Iinuma, Yoshinori Nozawa.   

Abstract

We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis.

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Year:  2003        PMID： 12932141     DOI： 10.1021/np020546u

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  35 in total

1.  Cytotoxic and NF-κB inhibitory constituents of the stems of Cratoxylum cochinchinense and their semisynthetic analogues.

Authors:  Yulin Ren; Susan Matthew; Daniel D Lantvit; Tran Ngoc Ninh; Heebyung Chai; James R Fuchs; Djaja D Soejarto; Esperanza J Carcache de Blanco; Steven M Swanson; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2011-03-23       Impact factor: 4.050

2.  Anti-angiogenic effect of α-mangostin.

Authors:  Tomoko Shiozaki; Miyuki Fukai; Elvira Hermawati; Lia Dewi Juliawaty; Yana Maolana Syah; Euis Holisotan Hakim; Ploenthip Puthongking; Toshihiro Suzuki; Kaoru Kinoshita; Kunio Takahashi; Kiyotaka Koyama
Journal:  J Nat Med       Date:  2012-03-02       Impact factor: 2.343

3.  In vivo toxicity and antitumor activity of mangosteen extract.

Authors:  Nuttavut Kosem; Kazuhiro Ichikawa; Hideo Utsumi; Primchanien Moongkarndi
Journal:  J Nat Med       Date:  2012-05-24       Impact factor: 2.343

4.  Structural Characterization, Biological Effects, and Synthetic Studies on Xanthones from Mangosteen (Garcinia mangostana), a Popular Botanical Dietary Supplement.

Authors:  Young-Won Chin; A Douglas Kinghorn
Journal:  Mini Rev Org Chem       Date:  2008-11-01       Impact factor: 2.495

5.  Overexpression of amyloid precursor protein induces susceptibility to oxidative stress in human neuroblastoma SH-SY5Y cells.

Authors:  K Matsumoto; Y Akao; H Yi; M Shamoto-Nagai; W Maruyama; M Naoi
Journal:  J Neural Transm (Vienna)       Date:  2005-06-15       Impact factor: 3.575

6.  Acute toxicity and teratogenicity of α-mangostin in zebrafish embryos.

Authors:  Wannakarn Kittipaspallop; Pornnarin Taepavarapruk; Chanpen Chanchao; Wittaya Pimtong
Journal:  Exp Biol Med (Maywood)       Date:  2019-01-02

7.  Anticancer effect and structure-activity analysis of marine products isolated from metabolites of mangrove fungi in the South China Sea.

Authors:  Li-yang Tao; Jian-ye Zhang; Yong-ju Liang; Li-ming Chen; Li-sheng Zhen; Fang Wang; Yan-jun Mi; Zhi-gang She; Kenneth Kin Wah To; Yong-cheng Lin; Li-wu Fu
Journal:  Mar Drugs       Date:  2010-04-01       Impact factor: 5.118

8.  A validated method for analysis of Swerchirin in Swertia longifolia Boiss. by high performance liquid chromatography.

Authors:  M Shekarchi; H Hajimehdipoor; M Khanavi; N Adib; M Bozorgi; B Akbari-Adergani
Journal:  Pharmacogn Mag       Date:  2010-02-13       Impact factor: 1.085

9.  Targeting truncated retinoid X receptor-α by CF31 induces TNF-α-dependent apoptosis.

Authors:  Guang-Hui Wang; Fu-Quan Jiang; Ying-Hui Duan; Zhi-Ping Zeng; Fan Chen; Yi Dai; Jie-Bo Chen; Jin-Xing Liu; Jie Liu; Hu Zhou; Hai-Feng Chen; Jin-Zhang Zeng; Ying Su; Xin-Sheng Yao; Xiao-Kun Zhang
Journal:  Cancer Res       Date:  2012-11-14       Impact factor: 12.701

10.  The effect of gartanin, a naturally occurring xanthone in mangosteen juice, on the mTOR pathway, autophagy, apoptosis, and the growth of human urinary bladder cancer cell lines.

Authors:  Zhongbo Liu; Mitchell Antalek; Linda Nguyen; Xuesen Li; Xuejiao Tian; Amy Le; Xiaolin Zi
Journal:  Nutr Cancer       Date:  2013       Impact factor: 2.900
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