Literature DB >> 12932133

Imidazole alkaloids from Lepidium meyenii.

Baoliang Cui1, Bo Lin Zheng, Kan He, Qun Yi Zheng.   

Abstract

Two new imidazole alkaloids (lepidiline A and lepidiline B) have been isolated from a root extract of Lepidium meyenii with the common name Maca and identified as 1,3-dibenzyl-4,5-dimethylimidazolium chloride (1) and 1,3-dibenzyl-2,4,5-trimethylimidazolium chloride (2), respectively. The structures of these two new compounds were determined by spectroscopic methods, as well as single-crystal X-ray diffraction performed on compound 1.

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Year:  2003        PMID： 12932133     DOI： 10.1021/np030031i

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  31 in total

1.  Synthesis, anti-proliferative activity, SAR study, and preliminary in vivo toxicity study of substituted N,N'-bis(arylmethyl)benzimidazolium salts against a panel of non-small cell lung cancer cell lines.

Authors:  Kerri L Shelton; Michael A DeBord; Patrick O Wagers; Marie R Southerland; Travis M Williams; Nikki K Robishaw; Leah P Shriver; Claire A Tessier; Matthew J Panzner; Wiley J Youngs
Journal:  Bioorg Med Chem       Date:  2016-11-05       Impact factor: 3.641

Review 2.  Membrane interactions of ionic liquids and imidazolium salts.

Authors:  Da Wang; Hans-Joachim Galla; Patrick Drücker
Journal:  Biophys Rev       Date:  2018-01-04

3.  Inhibition of Fatty Acid Amide Hydrolase (FAAH) by Macamides.

Authors:  M Alasmari; M Bӧhlke; C Kelley; T Maher; A Pino-Figueroa
Journal:  Mol Neurobiol       Date:  2018-06-20       Impact factor: 5.590

4.  Synthesis and antitumor activity of aza-brazilan derivatives containing imidazolium salt pharmacophores.

Authors:  Mingqin Huang; Shengzu Duan; Xueqiong Ma; Bicheng Cai; Dongmei Wu; Yan Li; Liang Li; Hongbin Zhang; Xiaodong Yang
Journal:  Medchemcomm       Date:  2019-05-10       Impact factor: 3.597

5.  Supported heteropoly acids offering strong option for efficient and cleaner processing for the synthesis of imidazole derivatives under solvent-free condition.

Authors:  Ezzat Rafiee; Houri Mahdavi; Mohammad Joshaghani
Journal:  Mol Divers       Date:  2010-01-26       Impact factor: 2.943

6.  Synthesis, characterization, in vitro SAR study, and preliminary in vivo toxicity evaluation of naphthylmethyl substituted bis-imidazolium salts.

Authors:  Marie R Southerland; Michael A DeBord; Nicholas A Johnson; Steven R Crabtree; Nicolas E Alexander; Michael L Stromyer; Patrick O Wagers; Matthew J Panzner; Chrys Wesdemiotis; Leah P Shriver; Claire A Tessier; Wiley J Youngs
Journal:  Bioorg Med Chem       Date:  2020-11-28       Impact factor: 3.641

7.  The influence of maca (Lepidium meyenii) on antioxidant status, lipid and glucose metabolism in rat.

Authors:  Rostislav Vecera; Jan Orolin; Nina Skottová; Ludmila Kazdová; Olena Oliyarnik; Jitka Ulrichová; Vilím Simánek
Journal:  Plant Foods Hum Nutr       Date:  2007-06       Impact factor: 4.124

8.  Effect of three different cultivars of Lepidium meyenii (Maca) on learning and depression in ovariectomized mice.

Authors:  Julio Rubio; Maria Caldas; Sonia Dávila; Manuel Gasco; Gustavo F Gonzales
Journal:  BMC Complement Altern Med       Date:  2006-06-23       Impact factor: 3.659

9.  Synthesis, characterization, and biological activity of a triphenylphosphonium-containing imidazolium salt against select bladder cancer cell lines.

Authors:  Michael L Stromyer; Marie R Southerland; Uttam Satyal; Rahmat K Sikder; David J Weader; Jessi A Baughman; Wiley J Youngs; Philip H Abbosh
Journal:  Eur J Med Chem       Date:  2019-10-31       Impact factor: 7.088

10.  Synthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives.

Authors:  Lan-Xiang Liu; Xue-Quan Wang; Bei Zhou; Li-Juan Yang; Yan Li; Hong-Bin Zhang; Xiao-Dong Yang
Journal:  Sci Rep       Date:  2015-08-19       Impact factor: 4.379
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