Literature DB >> 12931288

Wound-healing protocols for diabetic foot and pressure ulcers.

Harold Brem1, Tom Jacobs, Loretta Vileikyte, Sarah Weinberger, Mark Gibber, Kiran Gill, Alina Tarnovskaya, Hyacinth Entero, Andrew J M Boulton.   

Abstract

Diabetic foot and pressure ulcers are chronic wounds by definition. They share similar pathogeneses; i.e., a combination of increased pressure and decreased angiogenic response. Neuropathy, trauma, and deformity also often contribute to development of both types of ulcers. Early intervention and proper treatment should result in complete healing of non-ischemic diabetic foot and pressure ulcers, as defined by 100% epithelialization and no drainage (if no osteomyelitis is present). The authors developed the following paradigm, which has proved to be highly effective for complete healing of these wounds: 1) recognition that all patients with limited mobility are at risk for a sacral, ischial, trochanteric, or heel pressure ulcer; 2) daily self-examination of the sacral, ischium, buttocks, hips, and heels of all bed-bound patients and the feet of patients with diabetes with risk factors (e.g., neuropathy); 3) initiation of a treatment protocol immediately upon recognition of a break in the skin (i.e., emergence of a new wound); 4) objective measurement by planimetry of every wound (at a minimum, weekly) and documentation of its progress; 5) establishment of a moist wound-healing environment; 6) relief of pressure from the wound; 7) debridement of all non-viable tissue in the wound; 8) elimination of all drainage and cellulitis; 9) cellular therapy or growth factors for patients with wounds that do not heal rapidly after initial treatment; and 10) continuous physical and psychosocial support for all patients. If this paradigm is followed, most diabetic foot and pressure ulcers are expected to heal.

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Year:  2003        PMID: 12931288

Source DB:  PubMed          Journal:  Surg Technol Int        ISSN: 1090-3941


  16 in total

1.  Evaluation of Tielle hydropolymer dressings in the management of chronic exuding wounds in primary care.

Authors:  Curt Diehm; Holger Lawall
Journal:  Int Wound J       Date:  2005-03       Impact factor: 3.315

Review 2.  Pressure ulcers.

Authors:  Joseph E Grey; Keith G Harding; Stuart Enoch
Journal:  BMJ       Date:  2006-02-25

3.  Effects of a combined strengthening, stretching and functional training program versus usual-care on gait biomechanics and foot function for diabetic neuropathy: a randomized controlled trial.

Authors:  Cristina Dallemole Sartor; Ricky Watari; Anice Campos Pássaro; Andreja Paley Picon; Renata Haydée Hasue; Isabel C N Sacco
Journal:  BMC Musculoskelet Disord       Date:  2012-03-19       Impact factor: 2.362

4.  Regulation of impaired angiogenesis in diabetic dermal wound healing by microRNA-26a.

Authors:  Basak Icli; Christoph S Nabzdyk; Jorge Lujan-Hernandez; Meghan Cahill; Michael E Auster; A K M Wara; Xinghui Sun; Denizhan Ozdemir; Giorgio Giatsidis; Dennis P Orgill; Mark W Feinberg
Journal:  J Mol Cell Cardiol       Date:  2016-01-09       Impact factor: 5.000

5.  Using gene transcription patterns (bar coding scans) to guide wound debridement and healing.

Authors:  Marjana Tomic-Canic; Elizabeth A Ayello; Olivera Stojadinovic; Michael S Golinko; Harold Brem
Journal:  Adv Skin Wound Care       Date:  2008-10       Impact factor: 2.347

6.  OASIS wound matrix versus Hyaloskin in the treatment of difficult-to-heal wounds of mixed arterial/venous aetiology.

Authors:  Marco Romanelli; Valentina Dini; Mariastefania Bertone; Sabrina Barbanera; Cinzia Brilli
Journal:  Int Wound J       Date:  2007-03       Impact factor: 3.315

7.  Imbalance of angiogenesis in diabetic complications: the mechanisms.

Authors:  Zoya Tahergorabi; Majid Khazaei
Journal:  Int J Prev Med       Date:  2012-12

Review 8.  Reconstructive surgery for treating pressure ulcers.

Authors:  Jason Kf Wong; Kavit Amin; Jo C Dumville
Journal:  Cochrane Database Syst Rev       Date:  2016-12-06

9.  Conservative procedures in skin reconstitution.

Authors:  Uwe Wollina
Journal:  GMS Curr Top Otorhinolaryngol Head Neck Surg       Date:  2005-09-28

10.  Topical application of Sadat-Habdan mesenchymal stimulating peptide (SHMSP) accelerates wound healing in diabetic rabbits.

Authors:  Abdulmohsen H Al-Elq; Mir Sadat-Ali; Mohamed Elsharawy; Ibrahim Al-Habdan; Fatin Othman Al-Aqeel; Magda M Naim
Journal:  Exp Diabetes Res       Date:  2012-06-19
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