| Literature DB >> 12930392 |
Akira Tomonari1, Tohru Iseki, Satoshi Takahashi, Jun Ooi, Kashiya Takasugi, Yoko Shimohakamada, Nobuhiro Ohno, Fumitaka Nagamura, Kaoru Uchimaru, Kenzaburo Tani, Arinobu Tojo, Shigetaka Asano.
Abstract
Varicella-zoster virus (VZV) infection was studied in 40 adult patients who underwent cord blood transplantation (CBT) from unrelated donors. Twenty-five patients developed VZV reactivation at a median of 5 months after CBT (range 1.7-26 months). The cumulative incidence of VZV reactivation after CBT was 80% at 30 months. Twenty-two patients developed localized herpes zoster. The remaining three patients developed atypical non-localized herpes zoster, which was associated with visceral dissemination in one patient. All the patients responded well to antiviral therapy. Unexpectedly, the absence of grade II-IV acute graft-versus-host disease (GVHD) was associated with a higher rate of VZV reactivation after CBT (100% versus 55%, P=0.01). These results suggest that recovery of VZV-specific immune responses after CBT is delayed even in patients without severe acute GVHD.Entities:
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Year: 2003 PMID： 12930392 DOI： 10.1046/j.1365-2141.2003.04496.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998