| Literature DB >> 12929451 |
Miguel F Braña1, Mónica Cacho, Ana Ramos, M Teresa Domínguez, Jose M Pozuelo, Cristina Abradelo, M Fernanda Rey-Stolle, Mercedes Yuste, Carolina Carrasco, Christian Bailly.
Abstract
A novel series of mono and bisnaphthalimides was synthesized and their antiproliferative activities were evaluated against three tumor cell lines. Bisnaphthalimides 3 and 4, bearing a pyrazine ring fused to the naphthalimide system, showed activities in the order of 10(-8) microM, similar to elinafide. DNA binding properties and the ability to induce DNA damage were studied for some of the most active compounds.Entities:
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Year: 2003 PMID： 12929451 DOI： 10.1039/b209042b
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876