Literature DB >> 12929425

Total synthesis of (+/-)-rhazinal, an alkaloidal spindle toxin from Kopsia teoi.

Martin G Banwell1, Alison J Edwards, Katrina A Jolliffe, Jason A Smith, Ernest Hamel, Pascal Verdier-Pinard.   

Abstract

The title alkaloid 1 and its B-nor-congener 3, both of which display potent and unusual anti-mitotic properties, have been synthesized in racemic form and characterised by single-crystal X-ray analysis.

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Year:  2003        PMID： 12929425     DOI： 10.1039/b209992f

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  4 in total

1.  Total synthesis of (±)-leuconolam: intramolecular allylic silane addition to a maleimide carbonyl group.

Authors:  Enver Cagri Izgu; Thomas R Hoye
Journal:  Chem Sci       Date:  2013-02       Impact factor: 9.825

2.  Total synthesis of rhazinilam: axial to point chirality transfer in an enantiospecific Pd-catalyzed transannular cyclization.

Authors:  Zhenhua Gu; Armen Zakarian
Journal:  Org Lett       Date:  2010-10-01       Impact factor: 6.005

3.  o-(Trialkylstannyl)anilines and Their Utility in Stille Cross-Coupling: Direct Introduction of the 2-Aminophenyl Substituent.

Authors:  Enver Cagri Izgu; Thomas R Hoye
Journal:  Tetrahedron Lett       Date:  2012-09-12       Impact factor: 2.415

4.  Biosynthetically inspired divergent approach to monoterpene indole alkaloids: total synthesis of mersicarpine, leuconodines B and D, leuconoxine, melodinine E, leuconolam, and rhazinilam.

Authors:  Yang Yang; Yu Bai; Siyuan Sun; Mingji Dai
Journal:  Org Lett       Date:  2014-11-20       Impact factor: 6.005
  4 in total

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