PURPOSE: We investigated alterations in plasma nitrite, nitrate, total nitric oxide (NO*), and malondialdehyde (MDA) levels in patients with advanced stage laryngeal cancer. METHODS: We measured the levels of MDA and total NO2-, as well as the NO3- marker for NO* generation, in 25 patients with advanced laryngeal cancer and 15 healthy control subjects. RESULTS: The levels of plasma MDA, NO*, and NO3- were significantly higher in the patients with laryngeal cancer than in the healthy controls (P < 0.001 for all). On the other hand, although plasma NO2- was increased in the patient group, the statistical difference was not significant (P > 0.05). Moreover, the MDA and NO* levels did not differ significantly between patients with stage III and stage IV laryngeal cancer. CONCLUSION: These findings demonstrate that oxidative stress is increased in patients with advanced laryngeal cancer.
PURPOSE: We investigated alterations in plasma nitrite, nitrate, total nitric oxide (NO*), and malondialdehyde (MDA) levels in patients with advanced stage laryngeal cancer. METHODS: We measured the levels of MDA and total NO2-, as well as the NO3- marker for NO* generation, in 25 patients with advanced laryngeal cancer and 15 healthy control subjects. RESULTS: The levels of plasma MDA, NO*, and NO3- were significantly higher in the patients with laryngeal cancer than in the healthy controls (P < 0.001 for all). On the other hand, although plasma NO2- was increased in the patient group, the statistical difference was not significant (P > 0.05). Moreover, the MDA and NO* levels did not differ significantly between patients with stage III and stage IV laryngeal cancer. CONCLUSION: These findings demonstrate that oxidative stress is increased in patients with advanced laryngeal cancer.
Authors: Richard Salzman; Lukáš Pácal; Kateřina Kaňková; Josef Tomandl; Zuzana Horáková; Eva Tóthová; Rom Kostřica Journal: Int J Clin Oncol Date: 2010-07-15 Impact factor: 3.402
Authors: Giray Aynali; Mustafa Nazıroğlu; Ömer Çelik; Mustafa Doğan; Murat Yarıktaş; Hasan Yasan Journal: Eur Arch Otorhinolaryngol Date: 2013-03-12 Impact factor: 2.503
Authors: Abdullah Böyük; Akin Onder; Murat Kapan; Metehan Gümüş; Uğur Fιrat; Mustafa Kemal Başaralι; Harun Alp Journal: Pharmacogn Mag Date: 2011-07 Impact factor: 1.085