| Literature DB >> 12928514 |
Silviu Balan1, Arthur Leibovitz, Shen Orr Zila, Mishiev Ruth, Wechsler Chana, Blumenfeld Yassica, Biton Rahel, Goldstein Richard, Elon Neumann, Boris Blagman, Beni Habot.
Abstract
Delirium is a common syndrome among hospitalized elderly patients. In humans, sleep and circadian rhythms are disturbed during delirium, and both are influenced by the hormone melatonin. This prompted us to investigate the relationship of the clinical subtypes of delirium: 1). hyperactive, 2). hypoactive, and 3). mixed, with melatonin, as reflected by a patient's urinary metabolite 6-SMT. Results support our hypothesis that urinary 6-SMT during delirium was higher in hypoactive and lower in hyperactive patients. Because this is the first time a biochemical parameter related to the clinical subtypes of delirium has been reported, further research on the link between melatonin and delirium is necessary.Entities:
Mesh：
Substances：
Year: 2003 PMID： 12928514 DOI： 10.1176/jnp.15.3.363
Source DB: PubMed Journal: J Neuropsychiatry Clin Neurosci ISSN： 0895-0172 Impact factor: 2.198