| Literature DB >> 12926552 |
Barbara Zdzisińska1, Wojciech Rzeski, Roman Paduch, Agnieszka Szuster-Ciesielska, Józef Kaczor, Katarzyna Wejksza, Martyna Kandefer-Szerszeń.
Abstract
Betulin and betulinic acid, plant-derived triterpenoid compounds, have been described to possess anti-inflammatory activity. In this paper, we examine the ability of both compounds to induce and modulate cytokine production in human whole blood cell cultures. The results indicate that betulin is a modest TNF-alpha inducer and also an enhancer of mitogen-induced TNF-alpha production. In contrast to betulin, betulinic acid is a modulator of cytokine production by Th1/Th2 cell subpopulations which slightly enhances IL-10 formation and inhibits IFN-gamma production, reducing IFN-gamma/IL-10 ratio from 3.6 to 2.6.Entities:
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Year: 2003 PMID： 12926552
Source DB: PubMed Journal: Pol J Pharmacol ISSN： 1230-6002