Literature DB >> 12925690

Decrypting the role of Cripto in tumorigenesis.

Michael M Shen1.   

Abstract

The cell-surface associated molecule Cripto is overexpressed in a wide range of epithelial cancers, yet little is known about potential mechanisms by which Cripto expression might enhance tumorigenesis. A new study reveals that binding of Cripto to the TGF-beta ligand Activin B can block Activin B-mediated suppression of cell proliferation. Furthermore, this study also demonstrates that antibody blockade of Cripto function may prove useful in the inhibition of tumorigenesis.

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Year:  2003        PMID： 12925690      PMCID： PMC171399          DOI： 10.1172/JCI19546

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  18 in total

Review 1.  Nodal signaling in early vertebrate embryos: themes and variations.

Authors:  M Whitman
Journal:  Dev Cell       Date:  2001-11       Impact factor: 12.270

2.  Fucosylation of Cripto is required for its ability to facilitate nodal signaling.

Authors:  S G Schiffer; S Foley; A Kaffashan; X Hronowski; A E Zichittella; C Y Yeo; K Miatkowski; H B Adkins; B Damon; M Whitman; D Salomon; M Sanicola; K P Williams
Journal:  J Biol Chem       Date:  2001-08-10       Impact factor: 5.157

3.  A Nodal- and ALK4-independent signaling pathway activated by Cripto-1 through Glypican-1 and c-Src.

Authors:  Caterina Bianco; Luigi Strizzi; Aasia Rehman; Nicola Normanno; Christian Wechselberger; Youping Sun; Nadia Khan; Morihisa Hirota; Heather Adkins; Kevin Williams; Richard U Margolis; Michele Sanicola; David S Salomon
Journal:  Cancer Res       Date:  2003-03-15       Impact factor: 12.701

4.  Cripto forms a complex with activin and type II activin receptors and can block activin signaling.

Authors:  Peter C Gray; Craig A Harrison; Wylie Vale
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-07       Impact factor: 11.205

5.  Expression of cripto, a novel gene of the epidermal growth factor gene family, leads to in vitro transformation of a normal mouse mammary epithelial cell line.

Authors:  F Ciardiello; R Dono; N Kim; M G Persico; D S Salomon
Journal:  Cancer Res       Date:  1991-02-01       Impact factor: 12.701

6.  Inhibition of CRIPTO expression and tumorigenicity in human colon cancer cells by antisense RNA and oligodeoxynucleotides.

Authors:  F Ciardiello; G Tortora; C Bianco; M P Selvam; F Basolo; G Fontanini; F Pacifico; N Normanno; R Brandt; M G Persico
Journal:  Oncogene       Date:  1994-01       Impact factor: 9.867

7.  Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway.

Authors:  Yu-Ting Yan; Jan-Jan Liu; Yi Luo; Chaosu E; Robert S Haltiwanger; Cory Abate-Shen; Michael M Shen
Journal:  Mol Cell Biol       Date:  2002-07       Impact factor: 4.272

8.  EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1.

Authors:  Simon K Cheng; Felix Olale; James T Bennett; Ali H Brivanlou; Alexander F Schier
Journal:  Genes Dev       Date:  2003-01-01       Impact factor: 11.361

9.  Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo.

Authors:  Heather B Adkins; Caterina Bianco; Susan G Schiffer; Paul Rayhorn; Mohammad Zafari; Anne E Cheung; Olivia Orozco; Dian Olson; Antonella De Luca; Ling Ling Chen; Konrad Miatkowski; Chris Benjamin; Nicola Normanno; Kevin P Williams; Matthew Jarpe; Doreen LePage; David Salomon; Michele Sanicola
Journal:  J Clin Invest       Date:  2003-08       Impact factor: 14.808

10.  Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells.

Authors:  A Ciccodicola; R Dono; S Obici; A Simeone; M Zollo; M G Persico
Journal:  EMBO J       Date:  1989-07       Impact factor: 11.598
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  6 in total

Review 1.  Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis.

Authors:  Peter C Gray; Wylie Vale
Journal:  FEBS Lett       Date:  2012-02-01       Impact factor: 4.124

2.  Cripto binds transforming growth factor beta (TGF-beta) and inhibits TGF-beta signaling.

Authors:  Peter C Gray; Gidi Shani; Kevin Aung; Jonathan Kelber; Wylie Vale
Journal:  Mol Cell Biol       Date:  2006-10-09       Impact factor: 4.272

3.  Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin.

Authors:  Ombretta Guardiola; Peggy Lafuste; Silvia Brunelli; Salvatore Iaconis; Thierry Touvier; Philippos Mourikis; Katrien De Bock; Enza Lonardo; Gennaro Andolfi; Ann Bouché; Giovanna L Liguori; Michael M Shen; Shahragim Tajbakhsh; Giulio Cossu; Peter Carmeliet; Gabriella Minchiotti
Journal:  Proc Natl Acad Sci U S A       Date:  2012-11-05       Impact factor: 11.205

4.  Human pluripotent embryonal carcinoma NTERA2 cl.D1 cells maintain their typical morphology in an angiomyogenic medium.

Authors:  Pedro D Simões; Teresa Ramos
Journal:  J Negat Results Biomed       Date:  2007-04-18

5.  Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors.

Authors:  Simon K Cheng; Felix Olale; Ali H Brivanlou; Alexander F Schier
Journal:  PLoS Biol       Date:  2004-02-17       Impact factor: 8.029

Review 6.  Cell based therapies in Parkinson's Disease.

Authors:  Madhuri Behari; Kapil Kumar Singhal
Journal:  Ann Neurosci       Date:  2011-04
  6 in total

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