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Literature DB >> 12925571

Fly models of Huntington's disease.

J Lawrence Marsh¹, Judit Pallos, Leslie M Thompson.

Abstract

Can Drosophila models be engineered that accurately reflect Huntington's disease (HD) and other neurological diseases and can they contribute to the search for treatments and cures? A number of publications seem to provide a resounding yes to that question. Here we seek to review some of the salient features of these models.

Entities: Disease Species

Mesh：

Year: 2003 PMID： 12925571 DOI： 10.1093/hmg/ddg271

Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150

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Cited

23 in total

Review 1. Progress and prospects for genetic modification of nonhuman primate models in biomedical research.

Authors: Anthony W S Chan
Journal: ILAR J Date: 2013

2. Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila.

Authors: Namita Agrawal; Judit Pallos; Natalia Slepko; Barbara L Apostol; Laszlo Bodai; Ling-Wen Chang; Ann-Shyn Chiang; Leslie Michels Thompson; J Lawrence Marsh
Journal: Proc Natl Acad Sci U S A Date: 2005-02-16 Impact factor: 11.205

3. A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43.

Authors: Nicholas A Lanson; Astha Maltare; Hanna King; Rebecca Smith; Ji Han Kim; J Paul Taylor; Thomas E Lloyd; Udai Bhan Pandey
Journal: Hum Mol Genet Date: 2011-04-12 Impact factor: 6.150

4. Cystamine and intrabody co-treatment confers additional benefits in a fly model of Huntington's disease.

Authors: S F Bortvedt; J A McLear; A Messer; A J Ahern-Rindell; W J Wolfgang
Journal: Neurobiol Dis Date: 2010-04-24 Impact factor: 5.996

5. Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity.

Authors: Charity T Aiken; Joan S Steffan; Cortnie M Guerrero; Hasan Khashwji; Tamas Lukacsovich; Danielle Simmons; Judy M Purcell; Kimia Menhaji; Ya-Zhen Zhu; Kim Green; Frank Laferla; Lan Huang; Leslie Michels Thompson; J Lawrence Marsh
Journal: J Biol Chem Date: 2009-08-26 Impact factor: 5.157

Fly models of Huntington's disease.

Review 1. Progress and prospects for genetic modification of nonhuman primate models in biomedical research.

2. Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila.

3. A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43.

4. Cystamine and intrabody co-treatment confers additional benefits in a fly model of Huntington's disease.

5. Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity.

6. Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease.

7. Experimental models for identifying modifiers of polyglutamine-induced aggregation and neurodegeneration.

8. Wild type huntingtin toxicity in yeast: Implications for the role of amyloid cross-seeding in polyQ diseases.

Review 9. Modeling Huntington disease in yeast: perspectives and future directions.

10. Drosophila ste-20 family protein kinase, hippo, modulates fat cell proliferation.